TY - JOUR
T1 - Fluctuations of Emax of the left ventricle
T2 - Effect of atrial natriuretic polypeptide
AU - Yambe, T.
AU - Yoshizawa, M.
AU - Taira, R.
AU - Tanaka, A.
AU - Iguchi, A.
AU - Tabayashi, K.
AU - Tobita, S.
AU - Nitta, S.
N1 - Funding Information:
This work was partly supported by a Grant-in-aid for Developmental Scientific Research (11480253) a Research Grant for Cardiovascular Diseases from the Ministry of Health and Welfare, and from the Program for Promotion of Fundamental Studies in Health Sciences of the Organization for Drug ADR Relief, R&D Promotion and Product Review of Japan.
PY - 2000
Y1 - 2000
N2 - Recently the circadian rhythm of fluctuations in heart rate variability (HRV) has gained increasing attention, and the use of appropriate treatment corresponding to the circadian rhythm has become an important issue. However, the question has been raised as to whether the rhythm of fluctuation is only limited to HRV, and if a rhythm is also present in the contraction of the heart. The mathematical technique of electrical circuit simulation of the cardiovascular system was used to observe the Emax rhythm. In this study, the therapeutic effect of various drugs, including atrial natriuretic polypeptide (ANP), was confirmed. The effect of inotropic drugs including ANP on Emax was observed, and the results based on an old and a new method of determining Emax. were examined. Furthermore, the chaos analysis of Emax was also made. The time series of Emax showed an increased complexity due to the administration of ANP. In conclusion, it might be important to consider not only the fluctuation of HRV, but also an analysis of the fluctuation in the contraction of the heart.
AB - Recently the circadian rhythm of fluctuations in heart rate variability (HRV) has gained increasing attention, and the use of appropriate treatment corresponding to the circadian rhythm has become an important issue. However, the question has been raised as to whether the rhythm of fluctuation is only limited to HRV, and if a rhythm is also present in the contraction of the heart. The mathematical technique of electrical circuit simulation of the cardiovascular system was used to observe the Emax rhythm. In this study, the therapeutic effect of various drugs, including atrial natriuretic polypeptide (ANP), was confirmed. The effect of inotropic drugs including ANP on Emax was observed, and the results based on an old and a new method of determining Emax. were examined. Furthermore, the chaos analysis of Emax was also made. The time series of Emax showed an increased complexity due to the administration of ANP. In conclusion, it might be important to consider not only the fluctuation of HRV, but also an analysis of the fluctuation in the contraction of the heart.
KW - Atrial natriuremic polypeptide
KW - E
KW - Fluctuation
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U2 - 10.1016/s0753-3322(01)90021-6
DO - 10.1016/s0753-3322(01)90021-6
M3 - Article
C2 - 11774863
AN - SCOPUS:10644220511
SN - 0753-3322
VL - 55
SP - 147
EP - 152
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
IS - SUPPL.1
ER -