Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

Yusuke Sato; Atsuko Honjo; Daisuke Ishikawa; Seiichi Nishizawa; Norio Teramae

doi:10.1039/c1cc11370d

Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

Yusuke Sato, Atsuko Honjo, Daisuke Ishikawa, Seiichi Nishizawa, Norio Teramae

SCI - Chemistry

Tohoku University

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)_n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

Original language	English
Pages (from-to)	5885-5887
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	20
DOIs	https://doi.org/10.1039/c1cc11370d
Publication status	Published - 2011 May 3

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abstract = "We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.",

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T1 - Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

AU - Sato, Yusuke

AU - Honjo, Atsuko

AU - Ishikawa, Daisuke

AU - Nishizawa, Seiichi

AU - Teramae, Norio

PY - 2011/5/3

Y1 - 2011/5/3

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AB - We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

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Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

Abstract

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