TY - GEN
T1 - Focused ultrasonic device for sonodynamic therapy in the human body
AU - Yasui, A.
AU - Haga, Yoichi
AU - Chen, J. J.
AU - Wada, H.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Sonodynamic therapy is a new modality based on the synergistic effect of ultrasound and a chemical compound referred to as "sonosensitizer" for treatment of diseased sites such as cancer. However, by external ultrasound exposure, it is difficult to transmit ultrasound deep within the human body at adequate intensity because of transmission losses caused by the difference of specific acoustic impedance between media. Therefore, the aim of this study is to develop focused ultrasonic transducers using concave-shaped PZT for localized sonodynamic therapy in the human body. A concave-shaped PET was fabricated from a bulk PZT using a high-speed micro-milling machine, and then repolarized for the optimized polarization direction. The measurement result of the acoustic field using a PVDF hydrophone indicated that (he ultrasound emitted from the transducer was successfully focused in three-dimensions. At the focal point, the measured peak intensity would be sufficient for sonodynamic therapy.
AB - Sonodynamic therapy is a new modality based on the synergistic effect of ultrasound and a chemical compound referred to as "sonosensitizer" for treatment of diseased sites such as cancer. However, by external ultrasound exposure, it is difficult to transmit ultrasound deep within the human body at adequate intensity because of transmission losses caused by the difference of specific acoustic impedance between media. Therefore, the aim of this study is to develop focused ultrasonic transducers using concave-shaped PZT for localized sonodynamic therapy in the human body. A concave-shaped PET was fabricated from a bulk PZT using a high-speed micro-milling machine, and then repolarized for the optimized polarization direction. The measurement result of the acoustic field using a PVDF hydrophone indicated that (he ultrasound emitted from the transducer was successfully focused in three-dimensions. At the focal point, the measured peak intensity would be sufficient for sonodynamic therapy.
KW - Concave shape
KW - Focused ultrasound
KW - Milling machining
KW - Repolarization
KW - Sonodynamic therapy
KW - Ultrasonic transducer
UR - http://www.scopus.com/inward/record.url?scp=33845343606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845343606&partnerID=8YFLogxK
U2 - 10.1109/MMB.2005.1548411
DO - 10.1109/MMB.2005.1548411
M3 - Conference contribution
AN - SCOPUS:33845343606
SN - 0780387112
SN - 9780780387119
T3 - 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
SP - 154
EP - 157
BT - 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
T2 - 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Y2 - 12 May 2005 through 15 May 2005
ER -
