Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Masafumi Hidaka; Keita Kosaka; Saori Tsushima; Chiyoko Uchida; Katsuhiko Takahashi; Noriko Takahashi; Masayoshi Tsubuki; Yukihiko Hara; Takafumi Uchida

doi:10.1016/j.bbrc.2018.03.212

Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Masafumi Hidaka, Keita Kosaka, Saori Tsushima, Chiyoko Uchida, Katsuhiko Takahashi, Noriko Takahashi, Masayoshi Tsubuki, Yukihiko Hara, Takafumi Uchida

AGR - Agricultural Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.

Original language	English
Pages (from-to)	681-687
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	499
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2018.03.212
Publication status	Published - 2018 May 15

Keywords

Caffeic acid
EGCG
Food polyphenols
Pin1
Prolyl isomerase
Tannic acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2018.03.212

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title = "Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1",

abstract = "We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.",

keywords = "Caffeic acid, EGCG, Food polyphenols, Pin1, Prolyl isomerase, Tannic acid",

author = "Masafumi Hidaka and Keita Kosaka and Saori Tsushima and Chiyoko Uchida and Katsuhiko Takahashi and Noriko Takahashi and Masayoshi Tsubuki and Yukihiko Hara and Takafumi Uchida",

note = "Funding Information: TU was supported by a Grant-in-Aid for Scientific Research Kiban (S) 20228006 and (A) 26252064 from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry Grant 25028A . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Hidaka, Masafumi

AU - Kosaka, Keita

AU - Tsushima, Saori

AU - Uchida, Chiyoko

AU - Takahashi, Katsuhiko

AU - Takahashi, Noriko

AU - Tsubuki, Masayoshi

AU - Hara, Yukihiko

AU - Uchida, Takafumi

N1 - Funding Information: TU was supported by a Grant-in-Aid for Scientific Research Kiban (S) 20228006 and (A) 26252064 from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry Grant 25028A . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018 Elsevier Inc.

PY - 2018/5/15

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N2 - We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.

AB - We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.

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KW - Prolyl isomerase

KW - Tannic acid

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Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Abstract

Keywords

UN SDGs

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