Foreword: State-of-the-art techniques of ART (Annihilation Radiation Tomography)

State-of-the-art techniques have been used to measure key aspects of human pathophysiology from the birth of annihilation radiation tomographic (ART) techniques. Molecular imaging now offers an array of tools to develop advanced diagnostic approaches and therapies for patients with life-threatening diseases such as Alzheimer disease, psychiatric disease, and cancer. The ability to quantify molecules non-invasively in the brains of living human subjects has provided a means to begin to apply this technology not only as a diagnostic agent to detect regional molecular concentrations, but also as a surrogate marker of therapeutic efficacy in drug development.