Formal synthesis of hepatitis C Virus NS5B polymerase inhibitor

Takahiro Noro; Kentaro Okano; Hidetoshi Tokuyama

doi:10.1055/s-0033-1339522

Formal synthesis of hepatitis C Virus NS5B polymerase inhibitor

Takahiro Noro, Kentaro Okano, Hidetoshi Tokuyama

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A formal synthesis of a hepatitis C virus (HCV) inhibitor is described. The synthesis features a benzyne-mediated one-pot indoline formation-methylation sequence and an In(OTf)₃-mediated mild oxa-Pictet-Spengler reaction for the synthesis of substituted electron-rich pyranoindole.

Original language	English
Article number	ST-2013-U0562-L
Pages (from-to)	2143-2147
Number of pages	5
Journal	Synlett
Volume	24
Issue number	16
DOIs	https://doi.org/10.1055/s-0033-1339522
Publication status	Published - 2013 Aug 28

Keywords

benzyne
magnesium
one-pot
tandem reaction
total synthesis

ASJC Scopus subject areas

Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1055/s-0033-1339522

Cite this

@article{b5aac63522bd45a484da15fb025b225d,

title = "Formal synthesis of hepatitis C Virus NS5B polymerase inhibitor",

abstract = "A formal synthesis of a hepatitis C virus (HCV) inhibitor is described. The synthesis features a benzyne-mediated one-pot indoline formation-methylation sequence and an In(OTf)3-mediated mild oxa-Pictet-Spengler reaction for the synthesis of substituted electron-rich pyranoindole.",

keywords = "benzyne, magnesium, one-pot, tandem reaction, total synthesis",

author = "Takahiro Noro and Kentaro Okano and Hidetoshi Tokuyama",

year = "2013",

month = aug,

day = "28",

doi = "10.1055/s-0033-1339522",

language = "English",

volume = "24",

pages = "2143--2147",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "16",

}

TY - JOUR

T1 - Formal synthesis of hepatitis C Virus NS5B polymerase inhibitor

AU - Noro, Takahiro

AU - Okano, Kentaro

AU - Tokuyama, Hidetoshi

PY - 2013/8/28

Y1 - 2013/8/28

N2 - A formal synthesis of a hepatitis C virus (HCV) inhibitor is described. The synthesis features a benzyne-mediated one-pot indoline formation-methylation sequence and an In(OTf)3-mediated mild oxa-Pictet-Spengler reaction for the synthesis of substituted electron-rich pyranoindole.

AB - A formal synthesis of a hepatitis C virus (HCV) inhibitor is described. The synthesis features a benzyne-mediated one-pot indoline formation-methylation sequence and an In(OTf)3-mediated mild oxa-Pictet-Spengler reaction for the synthesis of substituted electron-rich pyranoindole.

KW - benzyne

KW - magnesium

KW - one-pot

KW - tandem reaction

KW - total synthesis

UR - http://www.scopus.com/inward/record.url?scp=84882504397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882504397&partnerID=8YFLogxK

U2 - 10.1055/s-0033-1339522

DO - 10.1055/s-0033-1339522

M3 - Article

AN - SCOPUS:84882504397

SN - 0936-5214

VL - 24

SP - 2143

EP - 2147

JO - Synlett

JF - Synlett

IS - 16

M1 - ST-2013-U0562-L

ER -

Formal synthesis of hepatitis C Virus NS5B polymerase inhibitor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this