Abstract
A formal synthesis of pseudolaric acid B, a diterpene isolated from the root bark of Pseudolarix kaempferi Gordon (Pinaceae), to Trost's synthetic intermediate was achieved in 17 steps from a known ketone. Key features of this synthesis include a Claisen rearrangement and iodoetherification to construct quaternary stereocenters and ring-closing metathesis to form the seven-membered ring.
| Original language | English |
|---|---|
| Pages (from-to) | 907-910 |
| Number of pages | 4 |
| Journal | Synlett |
| Volume | 31 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2020 Jun 3 |
Keywords
- Claisen rearrangement
- cytotoxins
- diterpenes
- iodoetherification
- pseudolaric acid B
- total synthesis