TY - JOUR
T1 - Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film
AU - Tanaka, Masaru
AU - Yoshizawa, Keiko
AU - Tsuruma, Akinori
AU - Sunami, Hiroshi
AU - Yamamoto, Sadaaki
AU - Shimomura, Masatsugu
N1 - Funding Information:
This work is supported by Grants-in-Aid and CREST from Japan Science and Technology Corporation (JST), and Special Coordination Funds for Promoting Science and Technology of Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2008/2/1
Y1 - 2008/2/1
N2 - The design of nano- and microstructures based on self-organization is a key area of research in the search for new biomaterials, and such structures have a variety of potential applications in tissue engineering scaffolds. We have reported a honeycomb-patterned polymer film (honeycomb film) with highly regular pores that is formed by self-organization. In order to utilize the honeycomb film as a scaffold for bone tissue engineering, hydroxyapatite (HA) was formed on the honeycomb film. In this study, we prepared a 3D scaffold comprising HA and a poly(ε-caprolactone) honeycomb film in a simulated body fluid (SBF) by changing the degree of hydrophilicity of the film. We investigated the dependence of the amount of HA formed on the length of time for which hydrolysis and soaking in SBF were carried out. Further, we characterized the crystallinity of the HA thus formed. We clarified that the amount of HA formed and its crystallinity were controlled by the length of time for which hydrolysis and soaking of the film were carried out. These HA-deposited honeycomb films, which have the HA microstructure, could serve as a novel scaffold for bone tissue engineering.
AB - The design of nano- and microstructures based on self-organization is a key area of research in the search for new biomaterials, and such structures have a variety of potential applications in tissue engineering scaffolds. We have reported a honeycomb-patterned polymer film (honeycomb film) with highly regular pores that is formed by self-organization. In order to utilize the honeycomb film as a scaffold for bone tissue engineering, hydroxyapatite (HA) was formed on the honeycomb film. In this study, we prepared a 3D scaffold comprising HA and a poly(ε-caprolactone) honeycomb film in a simulated body fluid (SBF) by changing the degree of hydrophilicity of the film. We investigated the dependence of the amount of HA formed on the length of time for which hydrolysis and soaking in SBF were carried out. Further, we characterized the crystallinity of the HA thus formed. We clarified that the amount of HA formed and its crystallinity were controlled by the length of time for which hydrolysis and soaking of the film were carried out. These HA-deposited honeycomb films, which have the HA microstructure, could serve as a novel scaffold for bone tissue engineering.
KW - Honeycomb
KW - Hydroxyapatite
KW - Porous
KW - Scaffold
KW - Self-organization
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U2 - 10.1016/j.colsurfa.2007.05.081
DO - 10.1016/j.colsurfa.2007.05.081
M3 - Article
AN - SCOPUS:37349100115
SN - 0927-7757
VL - 313-314
SP - 515
EP - 519
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
ER -