Frequency doubling technology and scanning laser tomography in eyes with generalized enlargement of optic disc cupping

Shiho Kunimatsu, Goji Tomita, Makoto Araie, Makoto Aihara, Yasuyuki Suzuki, Aiko Iwase, Nobuyuki Koseki, Shun Matsumoto, Yoshio Yamazaki, Keiji Yoshikawa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Purpose: To characterize functional and structural changes in eyes with generalized enlargement of optic disc cupping (vertical cup/disc ratio ≥0.8), normal intraocular pressure, normal standard achromatic automated perimetry (SAP) results, and no other ophthalmoscopic findings suggesting glaucoma (large C/D eyes) using frequency doubling technology (FDT) and the Heidelberg Retina Tomograph (HRT). Methods: This comparative observational case series included 30 large C/D eyes (30 subjects), 17 eyes (17 patients) with early-stage normal tension glaucoma with generalized enlargement of optic disc cupping (NTG eyes), and 25 eyes from 25 normal subjects (normal eyes). Results with Humphrey 30-2, FDT N-30 threshold programs, and HRT were compared among these groups. Large C/D eyes were subdivided into FDT-normal and -abnormal eyes according to the predetermined criteria and HRT parameters were compared among them. Results: No significant difference was seen in HRT parameters between the large C/D and NTG eyes. In the large C/D eyes, FDT mean deviation was lower than in the normal eyes and higher than in the NTG eyes, whereas FDT pattern standard deviation was smaller than in the NTG eyes (P = 0.02-0.03). Among HRT parameters, only cup shape measure (CSM) showed significant negative correlation with FDT mean deviation in the large C/D eyes. Between FDT-normal and -abnormal subgroups, only CSM showed significant difference (P < 0.01). Conclusion: Frequency doubling technology showed abnormalities in large C/D eyes. Only CSM showed significant correlation with FDT result and difference between those with normal and abnormal FDT results. In management of large C/D eyes, FDT and CSM will be useful to detect functional and structural change.

Original languageEnglish
Pages (from-to)280-287
Number of pages8
JournalJournal of Glaucoma
Issue number4
Publication statusPublished - 2005 Aug


  • Cup shape measure
  • Frequency doubling technology
  • Large C/D eyes
  • Large cup/disc ratio
  • Normal-tension glaucoma
  • Scanning laser tomography
  • Standard achromatic automated perimetry
  • The Heidelberg retina tomograph

ASJC Scopus subject areas

  • Ophthalmology


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