Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2

Reiko Saito; Takatsugu Sakai; Isamu Sato; Yasuko Sano; Hitoshi Oshitani; Mizuho Sato; Hiroshi Suzuki

doi:10.1128/JCM.41.5.2164-2165.2003

Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2

Reiko Saito, Takatsugu Sakai, Isamu Sato, Yasuko Sano, Hitoshi Oshitani, Mizuho Sato, Hiroshi Suzuki

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

In two influenza seasons during which H1N1 and H3N2 cocirculated, resistance was more frequent in H3N2 strains than in H1N1 strains after amantadine treatment. Predominant amino acid substitutions in M2 protein occurred at position 31 (serine to asparagine) in H3N2 strains and at position 27 (valine to alanine) in H1N1 strains.

Original language	English
Pages (from-to)	2164-2165
Number of pages	2
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1128/JCM.41.5.2164-2165.2003
Publication status	Published - 2003 May 1

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10.1128/JCM.41.5.2164-2165.2003

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abstract = "In two influenza seasons during which H1N1 and H3N2 cocirculated, resistance was more frequent in H3N2 strains than in H1N1 strains after amantadine treatment. Predominant amino acid substitutions in M2 protein occurred at position 31 (serine to asparagine) in H3N2 strains and at position 27 (valine to alanine) in H1N1 strains.",

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AU - Saito, Reiko

AU - Sakai, Takatsugu

AU - Sato, Isamu

AU - Sano, Yasuko

AU - Oshitani, Hitoshi

AU - Sato, Mizuho

AU - Suzuki, Hiroshi

PY - 2003/5/1

Y1 - 2003/5/1

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AB - In two influenza seasons during which H1N1 and H3N2 cocirculated, resistance was more frequent in H3N2 strains than in H1N1 strains after amantadine treatment. Predominant amino acid substitutions in M2 protein occurred at position 31 (serine to asparagine) in H3N2 strains and at position 27 (valine to alanine) in H1N1 strains.

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JO - Journal of Clinical Microbiology

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ER -

Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2

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