TY - JOUR
T1 - Fruitless and Doublesex Coordinate to Generate Male-Specific Neurons that Can Initiate Courtship
AU - Kimura, Ken ichi
AU - Hachiya, Tomoaki
AU - Koganezawa, Masayuki
AU - Tazawa, Tatsunori
AU - Yamamoto, Daisuke
N1 - Funding Information:
We thank E. Nilsson and H. Ito for their critical reading of the manuscript, B. Oliver for providing us with an aliquot of the anti-DsxM antibody, B. Dickson for the fru M and fru Gal4 fly stocks, A. Hofbauer for the monoclonal nc82 antibody, K. Ito for the fru NP21 strain, A. Gould for the Df(3L)H99 FRT A2 strain, A. Bloomington and Kyoto Stock Centers for other Drosophila strains, H. Aonuma for the use of a confocal microscope, Y. Shimada and Y. Fujita for secretarial assistance. This work was supported by a Specially Promoted Research Grant (No. 1802012) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to K.-i.K. and D.Y., Tohoku Neuroscience GCOE program grant from MEXT to D.Y., a KAKENHI (C) grant (No. 18570065) from MEXT to K.-i.K., and a Research Grant from The Akiyama Foundation to K.-i.K.
PY - 2008/9/11
Y1 - 2008/9/11
N2 - Biologists postulate that sexual dimorphism in the brain underlies gender differences in behavior, yet direct evidence for this has been sparse. We identified a male-specific, fruitless (fru)/doublesex (dsx)-coexpressing neuronal cluster, P1, in Drosophila. The artificial induction of a P1 clone in females effectively provokes male-typical behavior in such females even when the other parts of the brain are not masculinized. P1, located in the dorsal posterior brain near the mushroom body, is composed of 20 interneurons, each of which has a primary transversal neurite with extensive ramifications in the bilateral protocerebrum. P1 is fated to die in females through the action of a feminizing protein, DsxF. A masculinizing protein Fru is required in the male brain for correct positioning of the terminals of P1 neurites. Thus, the coordinated actions of two sex determination genes, dsx and fru, confer the unique ability to initiate male-typical sexual behavior on P1 neurons.
AB - Biologists postulate that sexual dimorphism in the brain underlies gender differences in behavior, yet direct evidence for this has been sparse. We identified a male-specific, fruitless (fru)/doublesex (dsx)-coexpressing neuronal cluster, P1, in Drosophila. The artificial induction of a P1 clone in females effectively provokes male-typical behavior in such females even when the other parts of the brain are not masculinized. P1, located in the dorsal posterior brain near the mushroom body, is composed of 20 interneurons, each of which has a primary transversal neurite with extensive ramifications in the bilateral protocerebrum. P1 is fated to die in females through the action of a feminizing protein, DsxF. A masculinizing protein Fru is required in the male brain for correct positioning of the terminals of P1 neurites. Thus, the coordinated actions of two sex determination genes, dsx and fru, confer the unique ability to initiate male-typical sexual behavior on P1 neurons.
KW - DEVBIO
KW - MOLNEURO
UR - http://www.scopus.com/inward/record.url?scp=50849112749&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2008.06.007
DO - 10.1016/j.neuron.2008.06.007
M3 - Article
C2 - 18786359
AN - SCOPUS:50849112749
SN - 0896-6273
VL - 59
SP - 759
EP - 769
JO - Neuron
JF - Neuron
IS - 5
ER -