TY - JOUR
T1 - Frustoconical porous microneedle for electroosmotic transdermal drug delivery
AU - Terutsuki, Daigo
AU - Segawa, Reiji
AU - Kusama, Shinya
AU - Abe, Hiroya
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
This work was partly supported by Tohoku University Frontier Research program (FRiD), by A-STEP ( JPMJTR20UJ ) from Japan Science and Technology Agency and by Grant-in-Aids for Scientific Research S ( 22H04956 ) from the Ministry of Education, Culture, Sports, Science and Technology , Japan.
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/2
Y1 - 2023/2
N2 - A truncated cone-shaped porous microneedle (PMN) made of poly-glycidyl methacrylate was studied as a minimally invasive tool for transdermal drug delivery. The transdermal electrical resistance of a pig skin was evaluated during the indentation of the PMNs, revealing that the frustoconical PMN (300 μm height) significantly reduced the resistance of the skin by expanding the stratum corneum without penetrating into the skin. A thin film of poly (2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) was grafted onto the inner wall of the microchannels of the frustoconical PMN to generate electroosmotic flow (EOF) upon current application in the direction of injection of the drug into the skin. Owing to the synergy of the expansion of the stratum corneum and the EOF-promotion, the PAMPS-modified frustoconical PMN effectively enhances the penetration of larger (over 500 Da) molecules, such as dextran (∼10 kDa).
AB - A truncated cone-shaped porous microneedle (PMN) made of poly-glycidyl methacrylate was studied as a minimally invasive tool for transdermal drug delivery. The transdermal electrical resistance of a pig skin was evaluated during the indentation of the PMNs, revealing that the frustoconical PMN (300 μm height) significantly reduced the resistance of the skin by expanding the stratum corneum without penetrating into the skin. A thin film of poly (2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) was grafted onto the inner wall of the microchannels of the frustoconical PMN to generate electroosmotic flow (EOF) upon current application in the direction of injection of the drug into the skin. Owing to the synergy of the expansion of the stratum corneum and the EOF-promotion, the PAMPS-modified frustoconical PMN effectively enhances the penetration of larger (over 500 Da) molecules, such as dextran (∼10 kDa).
KW - Electroosmosis
KW - Frustoconical protrusion
KW - Porous microneedle
KW - Transdermal delivery
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U2 - 10.1016/j.jconrel.2023.01.055
DO - 10.1016/j.jconrel.2023.01.055
M3 - Article
AN - SCOPUS:85146844821
SN - 0168-3659
VL - 354
SP - 694
EP - 700
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -