TY - JOUR
T1 - F1-ATPase rotation and its inhibition from the viewpoint of solvent entropy
AU - Yoshidome, Takashi
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10/16
Y1 - 2020/10/16
N2 - We compare the asymmetric packing of F1-ATPase and that of F1-ATPase containing the inhibitor protein IF1 (F1-ATPase(IF1)), which inhibits ATP hydrolysis. To analyze this asymmetric packing, we calculate the solvation entropy, S, of three subcomplexes. Subcomplexes I, II, and III contain βE, βTP, and βDP subunits, respectively. The order of |S| is subcomplex III < subcomplex II < subcomplex I for F1-ATPase, and subcomplex II < subcomplex III < subcomplex I for F1-ATPase(IF1). Thus, the packing of F1-ATPase and F1-ATPase(IF1) is different. We suggest a unified understanding of rotation and its inhibition from the viewpoint of the solvent entropy.
AB - We compare the asymmetric packing of F1-ATPase and that of F1-ATPase containing the inhibitor protein IF1 (F1-ATPase(IF1)), which inhibits ATP hydrolysis. To analyze this asymmetric packing, we calculate the solvation entropy, S, of three subcomplexes. Subcomplexes I, II, and III contain βE, βTP, and βDP subunits, respectively. The order of |S| is subcomplex III < subcomplex II < subcomplex I for F1-ATPase, and subcomplex II < subcomplex III < subcomplex I for F1-ATPase(IF1). Thus, the packing of F1-ATPase and F1-ATPase(IF1) is different. We suggest a unified understanding of rotation and its inhibition from the viewpoint of the solvent entropy.
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U2 - 10.1016/j.cplett.2020.137886
DO - 10.1016/j.cplett.2020.137886
M3 - Article
AN - SCOPUS:85089727107
SN - 0009-2614
VL - 757
JO - Chemical Physics Letters
JF - Chemical Physics Letters
M1 - 137886
ER -