[18F]THK-5351, a new candidate for tau protein imaging, is based on an aryl quinoline structure. We report the full automatic synthesis using disposable cassettes under pH controlled [18F]fluorination. After the trapping of 88.5 ± 21.9 GBq of [18F]fluoride, it was eluted with potassium methansulfonate (KOMs) (pH 7.8)/K222. After drying, 3 mg of the precursor was added to 1 mL DMSO and subjected to [18F]fluorination at 110 °C for 10 min. After hydrolysis, the final product was purified by HPLC. The overall radiochemical yield was 31.9 ± 11.1% (n = 22), satisfying all quality control criteria. It was stable for up to 6 h with high radiochemical purity as 99.8 ± 0.5%.
- Automatic synthesis
- PET imaging
- Tau protein positron emission tomography