Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

Masahito Miura; Jun Inoue; Mio Tsuruoka; Tsutomu Nishizawa; Shigeo Nagashima; Masaharu Takahashi; Tooru Shimosegawa; Hiroaki Okamoto

doi:10.1002/jmv.24743

Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

Masahito Miura, Jun Inoue, Mio Tsuruoka, Tsutomu Nishizawa, Shigeo Nagashima, Masaharu Takahashi, Tooru Shimosegawa, Hiroaki Okamoto

HOSP - Internal Medicine

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.

Original language	English
Pages (from-to)	1116-1120
Number of pages	5
Journal	Journal of Medical Virology
Volume	89
Issue number	6
DOIs	https://doi.org/10.1002/jmv.24743
Publication status	Published - 2017 Jun 1

Keywords

full genome
genotype 3
hepatitis viruses
phylogenetic analysis
subtype classification

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10.1002/jmv.24743

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Miura, M., Inoue, J., Tsuruoka, M., Nishizawa, T., Nagashima, S., Takahashi, M., Shimosegawa, T., & Okamoto, H. (2017). Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan. Journal of Medical Virology, 89(6), 1116-1120. https://doi.org/10.1002/jmv.24743

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title = "Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan",

abstract = "Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.",

keywords = "full genome, genotype 3, hepatitis viruses, phylogenetic analysis, subtype classification",

author = "Masahito Miura and Jun Inoue and Mio Tsuruoka and Tsutomu Nishizawa and Shigeo Nagashima and Masaharu Takahashi and Tooru Shimosegawa and Hiroaki Okamoto",

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Miura, M, Inoue, J, Tsuruoka, M, Nishizawa, T, Nagashima, S, Takahashi, M, Shimosegawa, T & Okamoto, H 2017, 'Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan', Journal of Medical Virology, vol. 89, no. 6, pp. 1116-1120. https://doi.org/10.1002/jmv.24743

Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan. / Miura, Masahito; Inoue, Jun; Tsuruoka, Mio et al.
In: Journal of Medical Virology, Vol. 89, No. 6, 01.06.2017, p. 1116-1120.

Research output: Contribution to journal › Article › peer-review

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T1 - Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

AU - Miura, Masahito

AU - Inoue, Jun

AU - Tsuruoka, Mio

AU - Nishizawa, Tsutomu

AU - Nagashima, Shigeo

AU - Takahashi, Masaharu

AU - Shimosegawa, Tooru

AU - Okamoto, Hiroaki

PY - 2017/6/1

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AB - Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.

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KW - genotype 3

KW - hepatitis viruses

KW - phylogenetic analysis

KW - subtype classification

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Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

Abstract

Keywords

UN SDGs

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