TY - JOUR
T1 - Fullerene–Oligonucleotide Conjugates
T2 - Photoinduced Sequence‐Specific DNA Cleavage
AU - Boutorine, Alexandre S.
AU - Takasugi, Masashi
AU - Hélène, Claude
AU - Tokuyama, Hidetoshi
AU - Isobe, Hiroyuki
AU - Nakamura, Eiichi
PY - 1995/1/3
Y1 - 1995/1/3
N2 - The guanine‐specific cleavage of oligonucleotides is achieved with the conjugate 1, which contains a fullerene tethered to a tetradecadeoxyribonucleotide Nu(pNu)n. This conjugate was able to form a duplex with a complementary oligonucleotide, and triplexes with appropriate double‐stranded oligonucleotides. Irradiation of the complexes leads to site‐specfic cleavage of the target sequences—probably through the action of singlet oxygen. (Figure Presented.)
AB - The guanine‐specific cleavage of oligonucleotides is achieved with the conjugate 1, which contains a fullerene tethered to a tetradecadeoxyribonucleotide Nu(pNu)n. This conjugate was able to form a duplex with a complementary oligonucleotide, and triplexes with appropriate double‐stranded oligonucleotides. Irradiation of the complexes leads to site‐specfic cleavage of the target sequences—probably through the action of singlet oxygen. (Figure Presented.)
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U2 - 10.1002/anie.199424621
DO - 10.1002/anie.199424621
M3 - Article
AN - SCOPUS:33751134818
SN - 1433-7851
VL - 33
SP - 2462
EP - 2465
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 23-24
ER -