Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment

Takayuki Kogure; Yoshiyuki Ueno; Koji Fukushima; Futoshi Nagasaki; Jun Inoue; Eiji Kakazu; Yasunori Matsuda; Osamu Kido; Yu Nakagome; Osamu Kimura; Noriyuki Obara; Yuta Wakui; Takao Iwasaki; Tooru Shimosegawa

doi:10.3748/wjg.v13.i32.4394

Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment

Takayuki Kogure, Yoshiyuki Ueno, Koji Fukushima, Futoshi Nagasaki, Jun Inoue, Eiji Kakazu, Yasunori Matsuda, Osamu Kido, Yu Nakagome, Osamu Kimura, Noriyuki Obara, Yuta Wakui, Takao Iwasaki, Tooru Shimosegawa

HOSP - Internal Medicine

Tohoku University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH.

Original language	English
Pages (from-to)	4394-4397
Number of pages	4
Journal	World Journal of Gastroenterology
Volume	13
Issue number	32
DOIs	https://doi.org/10.3748/wjg.v13.i32.4394
Publication status	Published - 2007 Aug 28

Keywords

Acute liver failure
Anti-viral therapy A
Autoimmune hepatitis
Hepatitis C virus
Interferon
Ribavirin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kogure, T., Ueno, Y., Fukushima, K., Nagasaki, F., Inoue, J., Kakazu, E., Matsuda, Y., Kido, O., Nakagome, Y., Kimura, O., Obara, N., Wakui, Y., Iwasaki, T., & Shimosegawa, T. (2007). Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment. World Journal of Gastroenterology, 13(32), 4394-4397. https://doi.org/10.3748/wjg.v13.i32.4394

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abstract = "A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH.",

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author = "Takayuki Kogure and Yoshiyuki Ueno and Koji Fukushima and Futoshi Nagasaki and Jun Inoue and Eiji Kakazu and Yasunori Matsuda and Osamu Kido and Yu Nakagome and Osamu Kimura and Noriyuki Obara and Yuta Wakui and Takao Iwasaki and Tooru Shimosegawa",

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Kogure, T, Ueno, Y, Fukushima, K, Nagasaki, F, Inoue, J, Kakazu, E, Matsuda, Y, Kido, O, Nakagome, Y, Kimura, O, Obara, N, Wakui, Y, Iwasaki, T & Shimosegawa, T 2007, 'Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment', World Journal of Gastroenterology, vol. 13, no. 32, pp. 4394-4397. https://doi.org/10.3748/wjg.v13.i32.4394

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T1 - Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment

AU - Kogure, Takayuki

AU - Ueno, Yoshiyuki

AU - Fukushima, Koji

AU - Nagasaki, Futoshi

AU - Inoue, Jun

AU - Kakazu, Eiji

AU - Matsuda, Yasunori

AU - Kido, Osamu

AU - Nakagome, Yu

AU - Kimura, Osamu

AU - Obara, Noriyuki

AU - Wakui, Yuta

AU - Iwasaki, Takao

AU - Shimosegawa, Tooru

PY - 2007/8/28

Y1 - 2007/8/28

N2 - A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH.

AB - A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH.

KW - Acute liver failure

KW - Anti-viral therapy A

KW - Autoimmune hepatitis

KW - Hepatitis C virus

KW - Interferon

KW - Ribavirin

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ER -

Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-inferferon-alpha 2b plus ribavirin treatment

Abstract

Keywords

UN SDGs

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