Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts

Kouetsu Ogasawara, Jonathan Benjamin, Rayna Takaki, Joseph H. Phillips, Lewis L. Lanier

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)


Irradiation-resistant natural killer (NK) cells in an F1 recipient can reject parental bone marrow, and host NK cells can also prevent engraftment of allogeneic bone marrow. We show here that repopulating bone marrow cells in certain mouse strains expressed retinoic acid early inducible 1 proteins, which are ligands for the activating NKG2D NK cell receptor. Treatment with a neutralizing antibody to NKG2D prevented rejection of parental BALB/c bone marrow in (C57BL/6 × BALB/c) F1 recipients and allowed engraftment of allogeneic BALB.B bone marrow in C57BL/6 recipients. Additionally, bone marrow from C57BL/6 mice transgenic for retinoic acid early inducible 1ε was rejected by syngeneic mice but was accepted after treatment with antibody to NKG2D. If other stem cells or tissues upregulate expression of NKG2D ligands after transplantation, NKG2D may contribute to graft rejection in immunocompetent hosts.

Original languageEnglish
Pages (from-to)938-945
Number of pages8
JournalNature Immunology
Issue number9
Publication statusPublished - 2005 Sept


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