Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities

Sayaka Watanabe; Fan Yan Wei; Kazuhito Tomizawa

doi:10.1016/j.ddmod.2012.12.001

Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities

Sayaka Watanabe, Fan Yan Wei, Kazuhito Tomizawa

IDAC - Division of Aging Science

Kumamoto University

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1.

Original language	English
Pages (from-to)	e65-e69
Journal	Drug Discovery Today: Disease Models
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmod.2012.12.001
Publication status	Published - 2013

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10.1016/j.ddmod.2012.12.001

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title = "Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities",

abstract = "Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1.",

author = "Sayaka Watanabe and Wei, {Fan Yan} and Kazuhito Tomizawa",

note = "Funding Information: This review was supported by the Japan Society for the Promotion of Science (JSPS) through its Funding Program for Next Generation World-Leading Researchers.",

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T1 - Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities

AU - Watanabe, Sayaka

AU - Wei, Fan Yan

AU - Tomizawa, Kazuhito

N1 - Funding Information: This review was supported by the Japan Society for the Promotion of Science (JSPS) through its Funding Program for Next Generation World-Leading Researchers.

PY - 2013

Y1 - 2013

N2 - Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1.

AB - Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1.

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SP - e65-e69

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

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ER -

Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities

Abstract

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