Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions

Sho Kakizawa; Shigeki Moriguchi; Atsushi Ikeda; Masamitsu Iino; Hiroshi Takeshima

doi:10.1007/s12311-008-0040-1

Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions

Sho Kakizawa, Shigeki Moriguchi, Atsushi Ikeda, Masamitsu Iino, Hiroshi Takeshima

PHA - Graduate School of Pharmaceutical Sciences (department affiliation only)

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.

Original language	English
Pages (from-to)	385-391
Number of pages	7
Journal	Cerebellum
Volume	7
Issue number	3
DOIs	https://doi.org/10.1007/s12311-008-0040-1
Publication status	Published - 2008 Sept

Keywords

Afterhyperpolarization
Ca release
Junctophilin
Long-term depression
Purkinje cell
Ryanodine receptor
Small-conductance Ca-activated K channel

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10.1007/s12311-008-0040-1

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abstract = "Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.",

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AU - Kakizawa, Sho

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AU - Ikeda, Atsushi

AU - Iino, Masamitsu

AU - Takeshima, Hiroshi

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AB - Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.

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KW - Ca release

KW - Junctophilin

KW - Long-term depression

KW - Purkinje cell

KW - Ryanodine receptor

KW - Small-conductance Ca-activated K channel

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Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions

Abstract

Keywords

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