TY - JOUR
T1 - Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila
AU - Thoma, Vladimiros
AU - Knapek, Stephan
AU - Arai, Shogo
AU - Hartl, Marion
AU - Kohsaka, Hiroshi
AU - Sirigrivatanawong, Pudith
AU - Abe, Ayako
AU - Hashimoto, Koichi
AU - Tanimoto, Hiromu
N1 - Funding Information:
We thank Hubert Amrein, John Carlson, Barret Pfeiffer, Gerald M. Rubin, Kristin Scott, Ilona Kadow, David Anderson and the Bloomington Stock Centre for fly stocks. We are grateful to Shoh Asano for help in Matlab programming, and Jessika Binder and Christian Garbers for developing preliminary software to estimate fly locomotion. We thank Christine Damrau for setting up the sugar preference assay and Pavel Maˇsek for sharing his expertise in the PER assay. This work was supported by the Bernstein Focus Neurobiology of Learning from Bundesministerium für Bildung und Forschung (01GQ0931/01GQ0932 to H.T.), Max-Planck-Gesellschaft (to H.T.), Deutsche Forschungsgemeinschaft (TA 552/5-1 to H.T.), MEXT/JSPS KAKENHI (25890003, 26120705, 26119503 and 26250001 to H.T.) and Naito Foundation (to H.T.). V.T. is a member of the International Max Planck Research School for Molecular and Cellular Life Sciences.
PY - 2016/2/19
Y1 - 2016/2/19
N2 - Finding food sources is essential for survival. Insects detect nutrients with external taste receptor neurons. Drosophila possesses multiple taste organs that are distributed throughout its body. However, the role of different taste organs in feeding remains poorly understood. By blocking subsets of sweet taste receptor neurons, we show that receptor neurons in the legs are required for immediate sugar choice. Furthermore, we identify two anatomically distinct classes of sweet taste receptor neurons in the leg. The axonal projections of one class terminate in the thoracic ganglia, whereas the other projects directly to the brain. These two classes are functionally distinct: the brain-projecting neurons are involved in feeding initiation, whereas the thoracic ganglia-projecting neurons play a role in sugar-dependent suppression of locomotion. Distinct receptor neurons for the same taste quality may coordinate early appetitive responses, taking advantage of the legs as the first appendages to contact food.
AB - Finding food sources is essential for survival. Insects detect nutrients with external taste receptor neurons. Drosophila possesses multiple taste organs that are distributed throughout its body. However, the role of different taste organs in feeding remains poorly understood. By blocking subsets of sweet taste receptor neurons, we show that receptor neurons in the legs are required for immediate sugar choice. Furthermore, we identify two anatomically distinct classes of sweet taste receptor neurons in the leg. The axonal projections of one class terminate in the thoracic ganglia, whereas the other projects directly to the brain. These two classes are functionally distinct: the brain-projecting neurons are involved in feeding initiation, whereas the thoracic ganglia-projecting neurons play a role in sugar-dependent suppression of locomotion. Distinct receptor neurons for the same taste quality may coordinate early appetitive responses, taking advantage of the legs as the first appendages to contact food.
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U2 - 10.1038/ncomms10678
DO - 10.1038/ncomms10678
M3 - Article
C2 - 26893070
AN - SCOPUS:84959036904
SN - 2041-1723
VL - 7
JO - Nature Communications
JF - Nature Communications
M1 - 10678
ER -