Gastric cancer complicated by synchronous gallbladder metastasis

Akihiro Yamamura, Koh Miura, Hideaki Karasawa, Chikashi Shibata, Makoto Kinouchi, Fumito Saijo, Tomohiko Sase, Kazuyuki Ishida, Iwao Sasaki

Research output: Contribution to journalArticlepeer-review


Only 11 cases of gallbladder metastasis, an extremely rare gastric cancer, have been reported in Japan. A 66-year-old Japanese woman with gastric cancer complicated by gallbladder metastasis was preop-eratively diagnosed with scirrhous gastric cancer free of noncurative factors such as peritoneal dissemination and distant metastasis. She underwent total gastrectomy, regional lymphadenectomy, splenec-tomy, and prophylactic cholecystectomy after neoadjuvant chemotherapy with TS-1 and CDDP. No macroscopic gallbladder abnormality was found but gastric cancer cells found in a histological examination to have spread to the gallbladder muscle layer were not considered part of direct invasion from either a primary tumor or peritoneal dissemination. They were, instead, thought to be lymphogenous gallbladder metastasis from gastric cancer because lymphatic invasion and lymphatic dilation were seen in the primary gastric lesion. The final histological diagnosis was poorly differentiated adenocarci-noma, T2 (SS), lyl, vO, Nl, HO, PI, CYO, Ml (gallbladder) and the histological response to neoadjuvant chemotherapy was evaluated as Grade 2. Although no adjuvant chemotherapy was done due to anorexia symptoms, she remains alive without recurrence in the 1 year since surgery. We discuss clinicopa-thological features with a review of the literature.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalJapanese Journal of Gastroenterological Surgery
Issue number1
Publication statusPublished - 2011 Jan


  • Gallbladder metastasis
  • Gastric cancer
  • Neoadjuvant chemotherapy


Dive into the research topics of 'Gastric cancer complicated by synchronous gallbladder metastasis'. Together they form a unique fingerprint.

Cite this