TY - JOUR
T1 - Gastric mucosal atrophy and prevalence of Helicobacter pylori in reflux esophagitis of the elderly
AU - Ohara, Shuichi
AU - Sekine, Hitoshi
AU - Iijima, Katsunori
AU - Moriyama, Satoru
AU - Nakayama, Yuichi
AU - Kinpara, Takayuki
AU - Kato, Katsuaki
AU - Asaki, Shigeru
AU - Katakura, Toshiki
AU - Ikeda, Takashi
AU - Toyota, Takayoshi
PY - 1996/4/1
Y1 - 1996/4/1
N2 - This study is aimed at a role of Helicobacter pylori (HP) infection in reflux esophagitis of the elderly. 46 patients with reflux esophagitis aged at older than 60 years are selected for this study with informed consent. 43 patients without reflux esophagitis, peptic ulcer, and gastric cancer are used as a control group. In reflux esophagitis, gastric mucosal atrophy is judged as closed type of endoscopic findings in all cases. In control, 27 of 43 patients were judged as open type. Serum pepsinogen I, II ratio is 4.73±1.28 which is higher significantly than 3.39±1.69 in control. Serological positive rate of HP antibody is 39.1% in reflux esophagitis. This rate is significantly lower than 62.7% in control. In conclusion, low frequency of chronic HP infection protects gastric mucosa from atrophy, and keeps secretion of gastric acid, resulting in reflux esophagitis of the elderly accompanied with various abnormal esophago-gastric functions.
AB - This study is aimed at a role of Helicobacter pylori (HP) infection in reflux esophagitis of the elderly. 46 patients with reflux esophagitis aged at older than 60 years are selected for this study with informed consent. 43 patients without reflux esophagitis, peptic ulcer, and gastric cancer are used as a control group. In reflux esophagitis, gastric mucosal atrophy is judged as closed type of endoscopic findings in all cases. In control, 27 of 43 patients were judged as open type. Serum pepsinogen I, II ratio is 4.73±1.28 which is higher significantly than 3.39±1.69 in control. Serological positive rate of HP antibody is 39.1% in reflux esophagitis. This rate is significantly lower than 62.7% in control. In conclusion, low frequency of chronic HP infection protects gastric mucosa from atrophy, and keeps secretion of gastric acid, resulting in reflux esophagitis of the elderly accompanied with various abnormal esophago-gastric functions.
KW - elderly
KW - gastric mucosal atrophy
KW - Helicobacter pylori
KW - pepsinogen
KW - reflux esophagitis
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M3 - Article
C2 - 8656565
AN - SCOPUS:9244261626
SN - 0446-6586
VL - 93
SP - 235
EP - 239
JO - Journal of Japanese Society of Gastroenterology
JF - Journal of Japanese Society of Gastroenterology
IS - 4
ER -
