Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety

Tomoko Mizuno; Masashi Aoki; Yuko Shimada; Midori Inoue; Kumi Nakaya; Toshiaki Takahashi; Yasuto Itoyama; Motoyori Kanazawa; Atsushi Utsumi; Yuka Endo; Taisuke Nomura; Masahiro Hiratsuka; Michinao Mizugaki; Junichi Goto; Michio Hongo; Shin Fukudo

doi:10.1016/j.jpsychores.2005.06.068

Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety

Tomoko Mizuno, Masashi Aoki, Yuko Shimada, Midori Inoue, Kumi Nakaya, Toshiaki Takahashi, Yasuto Itoyama, Motoyori Kanazawa, Atsushi Utsumi, Yuka Endo, Taisuke Nomura, Masahiro Hiratsuka, Michinao Mizugaki, Junichi Goto, Michio Hongo, Shin Fukudo

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Objective: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. Methods: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS). Results: There was significant Gender×Genotype interaction in STAI (state, P<.05; trait, P<.05). Females with the l/s genotype showed higher anxiety than those with the s/s genotype in both state and trait anxiety. Oppositely, males with the s/s genotype showed higher anxiety than those with the l/s genotype. Conclusion: On all emotional scales, females with the l/s genotype showed high scores, contrary to males with the same genotype. Therefore, our results suggest that 5-HTTLPR l allele may be one pathway that activates negative emotion in females but acts contrary in males.

Original language	English
Pages (from-to)	91-97
Number of pages	7
Journal	Journal of Psychosomatic Research
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/j.jpsychores.2005.06.068
Publication status	Published - 2006 Jan

Keywords

Anxiety
Depression
Gender
Gene (serotonin transporter promoter polymorphism)
Serotonin
Stress

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpsychores.2005.06.068

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Mizuno, T., Aoki, M., Shimada, Y., Inoue, M., Nakaya, K., Takahashi, T., Itoyama, Y., Kanazawa, M., Utsumi, A., Endo, Y., Nomura, T., Hiratsuka, M., Mizugaki, M., Goto, J., Hongo, M., & Fukudo, S. (2006). Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety. Journal of Psychosomatic Research, 60(1), 91-97. https://doi.org/10.1016/j.jpsychores.2005.06.068

Mizuno, T, Aoki, M, Shimada, Y, Inoue, M, Nakaya, K, Takahashi, T, Itoyama, Y, Kanazawa, M, Utsumi, A, Endo, Y, Nomura, T, Hiratsuka, M, Mizugaki, M, Goto, J, Hongo, M & Fukudo, S 2006, 'Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety', Journal of Psychosomatic Research, vol. 60, no. 1, pp. 91-97. https://doi.org/10.1016/j.jpsychores.2005.06.068

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title = "Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety",

abstract = "Objective: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. Methods: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS). Results: There was significant Gender×Genotype interaction in STAI (state, P<.05; trait, P<.05). Females with the l/s genotype showed higher anxiety than those with the s/s genotype in both state and trait anxiety. Oppositely, males with the s/s genotype showed higher anxiety than those with the l/s genotype. Conclusion: On all emotional scales, females with the l/s genotype showed high scores, contrary to males with the same genotype. Therefore, our results suggest that 5-HTTLPR l allele may be one pathway that activates negative emotion in females but acts contrary in males.",

keywords = "Anxiety, Depression, Gender, Gene (serotonin transporter promoter polymorphism), Serotonin, Stress",

author = "Tomoko Mizuno and Masashi Aoki and Yuko Shimada and Midori Inoue and Kumi Nakaya and Toshiaki Takahashi and Yasuto Itoyama and Motoyori Kanazawa and Atsushi Utsumi and Yuka Endo and Taisuke Nomura and Masahiro Hiratsuka and Michinao Mizugaki and Junichi Goto and Michio Hongo and Shin Fukudo",

note = "Funding Information: This research was supported by Grant-in-Aid for Scientific Research No. 7201-8863-15390218 and No. 7102-9209-15659145 from the Ministry of Education, Science, and Culture of Japan and Grant-in-Aid for Scientific Research No.H11-Nou-003, No. H13-Chouju-028, and H14-Si-9 from the Ministry of Health, Welfare, and Labor of Japan.",

year = "2006",

month = jan,

doi = "10.1016/j.jpsychores.2005.06.068",

language = "English",

volume = "60",

pages = "91--97",

journal = "Journal of Psychosomatic Research",

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T1 - Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety

AU - Mizuno, Tomoko

AU - Aoki, Masashi

AU - Shimada, Yuko

AU - Inoue, Midori

AU - Nakaya, Kumi

AU - Takahashi, Toshiaki

AU - Itoyama, Yasuto

AU - Kanazawa, Motoyori

AU - Utsumi, Atsushi

AU - Endo, Yuka

AU - Nomura, Taisuke

AU - Hiratsuka, Masahiro

AU - Mizugaki, Michinao

AU - Goto, Junichi

AU - Hongo, Michio

AU - Fukudo, Shin

N1 - Funding Information: This research was supported by Grant-in-Aid for Scientific Research No. 7201-8863-15390218 and No. 7102-9209-15659145 from the Ministry of Education, Science, and Culture of Japan and Grant-in-Aid for Scientific Research No.H11-Nou-003, No. H13-Chouju-028, and H14-Si-9 from the Ministry of Health, Welfare, and Labor of Japan.

PY - 2006/1

Y1 - 2006/1

N2 - Objective: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. Methods: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS). Results: There was significant Gender×Genotype interaction in STAI (state, P<.05; trait, P<.05). Females with the l/s genotype showed higher anxiety than those with the s/s genotype in both state and trait anxiety. Oppositely, males with the s/s genotype showed higher anxiety than those with the l/s genotype. Conclusion: On all emotional scales, females with the l/s genotype showed high scores, contrary to males with the same genotype. Therefore, our results suggest that 5-HTTLPR l allele may be one pathway that activates negative emotion in females but acts contrary in males.

AB - Objective: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. Methods: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS). Results: There was significant Gender×Genotype interaction in STAI (state, P<.05; trait, P<.05). Females with the l/s genotype showed higher anxiety than those with the s/s genotype in both state and trait anxiety. Oppositely, males with the s/s genotype showed higher anxiety than those with the l/s genotype. Conclusion: On all emotional scales, females with the l/s genotype showed high scores, contrary to males with the same genotype. Therefore, our results suggest that 5-HTTLPR l allele may be one pathway that activates negative emotion in females but acts contrary in males.

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KW - Depression

KW - Gender

KW - Gene (serotonin transporter promoter polymorphism)

KW - Serotonin

KW - Stress

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Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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