TY - JOUR
T1 - Gene expression profiling in whole cerebral cortices of phencyclidine- or methamphetamine-treated rats
AU - Ouchi, Yuta
AU - Kubota, Yasuhiko
AU - Kuramasu, Atsuo
AU - Watanabe, Takehiko
AU - Ito, Chihiro
N1 - Funding Information:
This work was supported by grants-in-aid for Scientific Research from the Japan Society of the Promotion of Science (JSPS) and a Target-Oriented Brain Science Research Program from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2005/10/31
Y1 - 2005/10/31
N2 - Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes. The number of MAP-, PCP-, and MAP and PCP-reactive tags were 229, 215, and 41, respectively.
AB - Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes. The number of MAP-, PCP-, and MAP and PCP-reactive tags were 229, 215, and 41, respectively.
KW - Cerebral cortex
KW - Methamphetamine
KW - Phencyclidine
KW - Schizophrenia: serial analysis of gene expression (SAGE)
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U2 - 10.1016/j.molbrainres.2005.07.011
DO - 10.1016/j.molbrainres.2005.07.011
M3 - Article
C2 - 16122833
AN - SCOPUS:26844467760
SN - 0169-328X
VL - 140
SP - 142
EP - 149
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -