Gene expression regulation and domain function of hematopoietic GATA factors

Ritsuko Shimizu; Masayuki Yamamoto

doi:10.1016/j.semcdb.2004.11.001

Gene expression regulation and domain function of hematopoietic GATA factors

Ritsuko Shimizu, Masayuki Yamamoto

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.

Original language	English
Pages (from-to)	129-136
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.semcdb.2004.11.001
Publication status	Published - 2005 Feb

Keywords

Complementation rescue
GATA-1
GATA-2
Gene regulatory networks

Access to Document

10.1016/j.semcdb.2004.11.001

Cite this

@article{e43ae21adafb4964ae5b98d8a260e255,

title = "Gene expression regulation and domain function of hematopoietic GATA factors",

abstract = "The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.",

keywords = "Complementation rescue, GATA-1, GATA-2, Gene regulatory networks",

author = "Ritsuko Shimizu and Masayuki Yamamoto",

note = "Funding Information: We thank Dr. Tania O{\textquoteright}Connor for her kind help in organizing the manuscript and we thank members of the MDB laboratory for helpful discussions. This work was supported in part by grants from JST ERATO, the Ministry of Education, Science, Sports and Culture (Advanced Research for Cancer and General Area), the Naito Foundation, and JSPS-RFTF.",

year = "2005",

month = feb,

doi = "10.1016/j.semcdb.2004.11.001",

language = "English",

volume = "16",

pages = "129--136",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - Gene expression regulation and domain function of hematopoietic GATA factors

AU - Shimizu, Ritsuko

AU - Yamamoto, Masayuki

N1 - Funding Information: We thank Dr. Tania O’Connor for her kind help in organizing the manuscript and we thank members of the MDB laboratory for helpful discussions. This work was supported in part by grants from JST ERATO, the Ministry of Education, Science, Sports and Culture (Advanced Research for Cancer and General Area), the Naito Foundation, and JSPS-RFTF.

PY - 2005/2

Y1 - 2005/2

N2 - The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.

AB - The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.

KW - Complementation rescue

KW - GATA-1

KW - GATA-2

KW - Gene regulatory networks

UR - http://www.scopus.com/inward/record.url?scp=12344282813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344282813&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2004.11.001

DO - 10.1016/j.semcdb.2004.11.001

M3 - Article

C2 - 15659347

AN - SCOPUS:12344282813

SN - 1084-9521

VL - 16

SP - 129

EP - 136

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 1

ER -

Gene expression regulation and domain function of hematopoietic GATA factors

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this