Genetic approaches for the identification of apoptotic components

Erina Kuranaga, Masayuki Miura

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Jun amino-terminal kinase (JNK) mediates a physiological stress signal that leads to cell death. However, the role of the JNK pathway in intrinsic cell death execution mechanisms is largely unknown. In a genetic screen for dominant suppressors of Reaper (Rpr)-induced cell death, we identified Drosophila chromosomal regions that contain genes which are homologous to apoptosis signal-regulating kinase (ASK1) and Drosophila tumor necrosis factor receptor-associated factor 1 (DTRAF1). We present evidence that the killer signal initiates the JNK pathway via proteasome-mediated degradation of Drosophila inhibitor of apoptosis protein 1 (DIAP1) to promote cell death.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalMedical Molecular Morphology
Issue number1
Publication statusPublished - 2005


  • Apoptosis
  • ASK1
  • Drosophila
  • IAPs
  • JNK
  • TRAFs


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