TY - JOUR
T1 - Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway
AU - Balanzà, Vicente
AU - Martínez-Fernández, Irene
AU - Sato, Shusei
AU - Yanofsky, Martin F.
AU - Kaufmann, Kerstin
AU - Angenent, Gerco C.
AU - Bemer, Marian
AU - Ferrándiz, Cristina
N1 - Funding Information:
We thank M. Schmid and D. Weigel (MPI, Tubingen) for sharing materials and M. Blazquez, F. Madueño (IBMCP), and J.J. Ripoll (UCSD), for helpful discussions. We also thank M.R. Ponce and J. L. Micol (Instituto de Bioingeniería, Universidad Miguel Hernández de Elche) for their help with the positional cloning of the AP2 gene and H. van Mourik (Wageningen University) for help with the ChIP-seq analysis. Our work was supported by grants from the Spanish DGI to C.F. (CSD2007-00057-B, BIO2012-32902, BIO2015-64531-R). V.B. was supported by a predoctoral fellowship of the Generalitat Valenciana.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Monocarpic plants have a single reproductive cycle in their lives, where life span is determined by the coordinated arrest of all meristems, or global proliferative arrest (GPA). The molecular bases for GPA and the signaling mechanisms involved are poorly understood, other than systemic cues from developing seeds of unknown nature. Here we uncover a genetic pathway regulating GPA in Arabidopsis that responds to age-dependent factors and acts in parallel to seed-derived signals. We show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, as GPA is delayed and fruit production is increased in ful mutants. FUL directly and negatively regulates APETALA2 expression in the shoot apical meristem and maintains the temporal expression of WUSCHEL which is an essential factor for meristem maintenance.
AB - Monocarpic plants have a single reproductive cycle in their lives, where life span is determined by the coordinated arrest of all meristems, or global proliferative arrest (GPA). The molecular bases for GPA and the signaling mechanisms involved are poorly understood, other than systemic cues from developing seeds of unknown nature. Here we uncover a genetic pathway regulating GPA in Arabidopsis that responds to age-dependent factors and acts in parallel to seed-derived signals. We show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, as GPA is delayed and fruit production is increased in ful mutants. FUL directly and negatively regulates APETALA2 expression in the shoot apical meristem and maintains the temporal expression of WUSCHEL which is an essential factor for meristem maintenance.
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U2 - 10.1038/s41467-018-03067-5
DO - 10.1038/s41467-018-03067-5
M3 - Article
C2 - 29422669
AN - SCOPUS:85041923018
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 565
ER -