TY - JOUR
T1 - Genetic diversity of HIV-1 group M from Cameroon and Republic of Congo
AU - Mboudjeka, I.
AU - Bikandou, B.
AU - Zekeng, L.
AU - Takehisa, J.
AU - Harada, Y.
AU - Yamaguchi-Kabata, Y.
AU - Taniguchi, Y.
AU - Ido, E.
AU - Kaptue, L.
AU - M'pelle, P.
AU - Parra, H. J.
AU - Ikeda, M.
AU - Hayami, M.
AU - Miura, T.
PY - 1999
Y1 - 1999
N2 - We analyzed 57 HIV-1 isolates from Cameroon and the Republic of Congo, with respect to the env C2V3 and/or the pol integrase regions. The results indicated that the topology of the pol tree correlated well with that of the env tree for four clusters of subtype D, F G and H, suggesting that these trees reflect the true evolution of the overall genome structures of these subtypes. However, of 22 Cameroonian isolates that were classified as subtype A based on env, 20 of them diverged in their pol sequence into two lineages that were completely different from the prototypical subtype A, tentatively designated as subtypes A1 and A2. The subtype A1 isolates (6 out of 22) were related in their env C2V3 regions with prototypical subtype A strain, but in their pol regions, they formed an independent cluster that diverged from known HIV-1 subtypes so far reported (except for subtypes I and J). The subtype A2 isolates (14 out of 22), which represent the major epidemic type of HIV-1 in Cameroon, clustered distinctly in both the env and pol trees with the recently described A/G mosaic strains from Nigeria and Djibouti. These two lineages were not spreading in the neighboring Republic of Congo.
AB - We analyzed 57 HIV-1 isolates from Cameroon and the Republic of Congo, with respect to the env C2V3 and/or the pol integrase regions. The results indicated that the topology of the pol tree correlated well with that of the env tree for four clusters of subtype D, F G and H, suggesting that these trees reflect the true evolution of the overall genome structures of these subtypes. However, of 22 Cameroonian isolates that were classified as subtype A based on env, 20 of them diverged in their pol sequence into two lineages that were completely different from the prototypical subtype A, tentatively designated as subtypes A1 and A2. The subtype A1 isolates (6 out of 22) were related in their env C2V3 regions with prototypical subtype A strain, but in their pol regions, they formed an independent cluster that diverged from known HIV-1 subtypes so far reported (except for subtypes I and J). The subtype A2 isolates (14 out of 22), which represent the major epidemic type of HIV-1 in Cameroon, clustered distinctly in both the env and pol trees with the recently described A/G mosaic strains from Nigeria and Djibouti. These two lineages were not spreading in the neighboring Republic of Congo.
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U2 - 10.1007/s007050050645
DO - 10.1007/s007050050645
M3 - Article
C2 - 10664385
AN - SCOPUS:0033394084
SN - 0304-8608
VL - 144
SP - 2291
EP - 2311
JO - Archives of Virology
JF - Archives of Virology
IS - 12
ER -
