TY - JOUR
T1 - Genetic features of Khoton Mongolians revealed by SNP analysis of the X chromosome
AU - Katoh, Toru
AU - Mano, Shuhei
AU - Munkhbat, Batmunkh
AU - Tounai, Kenichi
AU - Oyungerel, Ganjuur
AU - Chae, Gue Tae
AU - Han, Hoon
AU - Jia, Guan Jun
AU - Tokunaga, Katsushi
AU - Munkhtuvshin, Namid
AU - Tamiya, Gen
AU - Inoko, Hidetoshi
N1 - Funding Information:
We would like to thank Y. Yoshikawa, H. Ando, and E. Tokubo for their technical assistance. We are also grateful to P. Oyungerel, N. Chuluunjav, D. Altansukh, and M. Tomizawa for their help with the sample collection. This research was supported by a MEXT Grant-in-Aid for the 21st Century COE Program from the Ministry of Education, Culture, Sports, and Science, and Technology, Japan.
PY - 2005/9/12
Y1 - 2005/9/12
N2 - The Khoton Mongolian population is a small and relatively isolated ethnic group residing predominantly in the northwestern part of Mongolia. A recent genetic study of the Y chromosome revealed that the major Mongolian ethnic groups have a relatively close genetic affinity to populations in the northern part of East Asia, while the Khoton population reflected an apparent genetic differentiation from the other Mongolian populations. To further investigate the genetic features of the Khoton and the other Mongolian populations, we analyzed the single nucleotide polymorphisms (SNPs) in the Xq13.3 region, which is thought to have an extremely low level of recombination in the human X chromosome. We found that the frequency distribution of Xq13.3 haplotypes in the Khoton population was substantially different from those in three other Mongolian populations (Khalkh, Uriankhai, and Zakhchin). The same relationship was also revealed by the results from the population tree and principal-component (PC) analysis based on the allele frequencies. These results are largely consistent with the hypothesis that the Khoton population descended from a nomadic tribe of Turkish origin, which has been supported by previous anthropological, historical, and Y-chromosome studies. However, the population structure analysis produced an additional finding, namely, that the Khoton population is likely to be an admixed population.
AB - The Khoton Mongolian population is a small and relatively isolated ethnic group residing predominantly in the northwestern part of Mongolia. A recent genetic study of the Y chromosome revealed that the major Mongolian ethnic groups have a relatively close genetic affinity to populations in the northern part of East Asia, while the Khoton population reflected an apparent genetic differentiation from the other Mongolian populations. To further investigate the genetic features of the Khoton and the other Mongolian populations, we analyzed the single nucleotide polymorphisms (SNPs) in the Xq13.3 region, which is thought to have an extremely low level of recombination in the human X chromosome. We found that the frequency distribution of Xq13.3 haplotypes in the Khoton population was substantially different from those in three other Mongolian populations (Khalkh, Uriankhai, and Zakhchin). The same relationship was also revealed by the results from the population tree and principal-component (PC) analysis based on the allele frequencies. These results are largely consistent with the hypothesis that the Khoton population descended from a nomadic tribe of Turkish origin, which has been supported by previous anthropological, historical, and Y-chromosome studies. However, the population structure analysis produced an additional finding, namely, that the Khoton population is likely to be an admixed population.
KW - Mongolian
KW - Population structure
KW - SNP haplotype
KW - TaqMan assay
KW - X chromosome
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U2 - 10.1016/j.gene.2005.06.029
DO - 10.1016/j.gene.2005.06.029
M3 - Article
C2 - 16125340
AN - SCOPUS:24744437127
SN - 0378-1119
VL - 357
SP - 95
EP - 102
JO - Gene
JF - Gene
IS - 2
ER -