Genetic risk factors in senile dementia

H. Arai

Research output: Contribution to journalArticlepeer-review


Alzheimer's disease (AD) and vascular dementia (VD) are two major dementing disorders in Japan. It has been well established that apolipoprotein E4 (ApoE4) increases the incidence of AD and lower the onset of AD in a dose-dependent manner. ApoE genotyping should not be used alone in the diagnosis of AD due to its limited sensitivity to detect AD. In VD, at the present time, no genetic risk factors that are directly linked to VD have been established. However, methylenetetrahydrofolate reductase gene polymorphism may be a candidate conferring a risk to develop vascular diseases.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJapanese Journal of Geriatrics
Issue number4
Publication statusPublished - 1999


  • Alzheimer's disease
  • Apolipoprotein E
  • Methylentetrahydrofolate reductase gene
  • Vascular dementia

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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