TY - JOUR
T1 - Genome-wide association study for white coat effect in Japanese middle-aged to elderly people
T2 - The HOMED-BP study
AU - Ogata, Soshiro
AU - Kamide, Kei
AU - Asayama, Kei
AU - Tabara, Yasuharu
AU - Kawaguchi, Takahisa
AU - Satoh, Michihiro
AU - Katsuya, Tomohiro
AU - Sugimoto, Ken
AU - Hirose, Takuo
AU - Inoue, Ryusuke
AU - Hara, Azusa
AU - Obara, Taku
AU - Kikuya, Masahiro
AU - Metoki, Hirohito
AU - Matsuda, Fumihiko
AU - Staessen, Jan A.
AU - Ohkubo, Takayoshi
AU - Rakugi, Hiromi
AU - Imai, Yutaka
N1 - Funding Information:
This work was supported by the following grants: This study was supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (YI:25253059). Soshiro Ogata is supported by a post-doctoral fellowship in Japan Society for the Promotion of Science, Tokyo, Japan (JSPS KAKENHI Grant Number JP15J03698).
Funding Information:
The Japanese Society of Hypertension endorsed the HOMED-BP trial. Fujitsu Systems East Limited (Tokyo, Japan) and Omron Healthcare Co. (Kyoto, Japan) developed and maintained the internet-based infrastructure for the measurement of blood pressure at home and the management of patients. The HOMED-BP study was funded by grants from the Japan Cardiovascular Research Foundation, the Japan Arteriosclerosis Prevention Fund and Tohoku University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2018 Taylor & Francis.
PY - 2018/5/19
Y1 - 2018/5/19
N2 - Background: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. Methods: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10–4), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. Results: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10–7). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10–4). However, the consistent results were not obtained in the replication study. Conclusion: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.
AB - Background: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. Methods: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10–4), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. Results: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10–7). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10–4). However, the consistent results were not obtained in the replication study. Conclusion: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.
KW - epidemiology
KW - genome-wide association study
KW - Japan
KW - White coat effect
KW - white coat hypertension
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U2 - 10.1080/10641963.2017.1384481
DO - 10.1080/10641963.2017.1384481
M3 - Article
C2 - 29058489
AN - SCOPUS:85031894784
SN - 1064-1963
VL - 40
SP - 363
EP - 369
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 4
ER -