@article{ccbbd391e4c84ad79f499c9b54bc51fa,
title = "Genome-wide association study identifies 112 new loci for body mass index in the Japanese population",
abstract = "Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10-8), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies 112 novel loci, doubling the number of previously known BMI-associated loci. By annotating associated variants with cell-type-specific regulatory marks, we found enrichment of variants in CD19+ cells. We also found significant genetic correlations between BMI and lymphocyte count (P = 6.46 × 10-5, rg = 0.18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity.",
author = "Masato Akiyama and Yukinori Okada and Masahiro Kanai and Atsushi Takahashi and Yukihide Momozawa and Masashi Ikeda and Nakao Iwata and Shiro Ikegawa and Makoto Hirata and Koichi Matsuda and Motoki Iwasaki and Taiki Yamaji and Norie Sawada and Tsuyoshi Hachiya and Kozo Tanno and Atsushi Shimizu and Atsushi Hozawa and Naoko Minegishi and Shoichiro Tsugane and Masayuki Yamamoto and Michiaki Kubo and Yoichiro Kamatani",
note = "Funding Information: We would like to acknowledge the staff of the TMM, the JPHC and the BBJ for collecting samples and clinical information. We are grateful to the staff of the RIKEN Center for Integrative Medical Sciences for genotyping and data management. We thank S.K. Low, K. Suzuki and M. Horikoshi for advice on statistical analyses, and A.P. Morris for providing us with the MANTRA software. This study was funded by the BioBank Japan project (M.A., Y.O., M. Kanai, A.T., Y.M., M.H., K.M., M. Kubo and Y.K.) and Tohoku Medical Megabank project (T.H., K.T., A.S., A.H., N.M. and M.Y.), which is supported by the Ministry of Education, Culture, Sports, Sciences and Technology of Japanese government and the Japan Agency for Medical Research and Development. The JPHC Study has been supported by the National Cancer Research and Development Fund (2010–present) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (1989–2010) (M. Iwasaki., T.Y., N.S. and S.T.). GWAS of psychiatric disorders were the results of the Strategic Research Program for Brain Sciences (SRPBS) from the Japan Agency for Medical Research and Development (A.T., M. Ikeda, N.I., M. Kubo and Y.K.). Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature. All rights reserved.",
year = "2017",
month = oct,
day = "1",
doi = "10.1038/ng.3951",
language = "English",
volume = "49",
pages = "1458--1467",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",
}
