TY - JOUR
T1 - Genome-wide association study identifies new loci for albuminuria in the Japanese population
AU - Okuda, Hiroshi
AU - Okamoto, Koji
AU - Abe, Michiaki
AU - Ishizawa, Kota
AU - Makino, Satoshi
AU - Tanabe, Osamu
AU - Sugawara, Junichi
AU - Hozawa, Atsushi
AU - Tanno, Kozo
AU - Sasaki, Makoto
AU - Tamiya, Gen
AU - Yamamoto, Masayuki
AU - Ito, Sadayoshi
AU - Ishii, Tadashi
N1 - Funding Information:
This study was supported by the TMM Project (Special Account for Reconstruction from the Great East Japan Earthquake) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and the Japan Agency for Medical Research and Development (AMED). The authors sincerely express thanks to all the patients and volunteers who were enrolled in the ToMMo and IMM in the disaster-struck areas affected by the Great East Japan Earthquake. We thank the members of ToMMo and IMM, including GMRCs, office and administrative personnel, and software engineers, for their assistance in the projects. The full list of the members is available at https://www.megabank.tohoku.ac.jp/english/a190601/ for ToMMo and https://iwate-megabank.org/en/about/departments/ for IMM.
Funding Information:
This study was supported by the TMM Project (Special Account for Reconstruction from the Great East Japan Earthquake) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and the Japan Agency for Medical Research and Development (AMED). The authors sincerely express thanks to all the patients and volunteers who were enrolled in the ToMMo and IMM in the disaster-struck areas affected by the Great East Japan Earthquake. We thank the members of ToMMo and IMM, including GMRCs, office and administrative personnel, and software engineers, for their assistance in the projects. The full list of the members is available at https://www.megabank.tohoku.ac.jp/english/a190601/ for ToMMo and https://iwate-megabank.org/en/about/departments/ for IMM.
Publisher Copyright:
© 2020, Japanese Society of Nephrology.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Urinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. Here we conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. Methods: We conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM). The SNP genotype data were obtained with a SNP microarray. After imputation using a haplotype panel consisting of 2000 genome sequencing, 4,962,728 SNP markers were used for the GWAS. Results: Eighteen SNPs at 14 loci (GRM7, EXOC1/NMU, LPA, STEAP1B/RAPGEF5, SEMA3D, PRKAG2, TRIQK, SERTM1, TPT1-AS1, OR5AU1, TSHR, FMN1/RYR3, COPRS, and BRD1) were associated with UAE in the Japanese individuals. A locus with particularly strong associations was observed on TSHR, chromosome 14 [rs116622332 (p = 3.99 × 10−10)]. Conclusion: In this study, we successfully identified UAE-associated variant loci in the Japanese population. Further study is required to confirm this association.
AB - Background: Urinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. Here we conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. Methods: We conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM). The SNP genotype data were obtained with a SNP microarray. After imputation using a haplotype panel consisting of 2000 genome sequencing, 4,962,728 SNP markers were used for the GWAS. Results: Eighteen SNPs at 14 loci (GRM7, EXOC1/NMU, LPA, STEAP1B/RAPGEF5, SEMA3D, PRKAG2, TRIQK, SERTM1, TPT1-AS1, OR5AU1, TSHR, FMN1/RYR3, COPRS, and BRD1) were associated with UAE in the Japanese individuals. A locus with particularly strong associations was observed on TSHR, chromosome 14 [rs116622332 (p = 3.99 × 10−10)]. Conclusion: In this study, we successfully identified UAE-associated variant loci in the Japanese population. Further study is required to confirm this association.
KW - Albuminuria
KW - Cohort study
KW - GWAS
KW - Genetics
KW - QTL
KW - TSHR
UR - http://www.scopus.com/inward/record.url?scp=85083714333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083714333&partnerID=8YFLogxK
U2 - 10.1007/s10157-020-01884-x
DO - 10.1007/s10157-020-01884-x
M3 - Article
C2 - 32277301
AN - SCOPUS:85083714333
SN - 1342-1751
VL - 24
SP - 1
EP - 9
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 8
ER -
