@article{fef383c9ddc64549b39e35c2672189a9,
title = "Geographic range expansion of tetrodotoxin in amphibians – First record in Atelopus hoogmoedi from the Guiana Shield",
abstract = "For the first time, alcohol extracts of Atelopus hoogmoedi from the Guiana Shield in Suriname and Guyana were analyzed for the presence of tetrodotoxin (TTX) and of its analogues by high resolution hydrophilic interaction liquid chromatography/mass spectrometry. One specimen from Suriname was found to contain TTX and 4-epiTTX. Using a monoclonal antibody-based immunohistochemical staining technique, TTX was localized mainly in the granular glands and epithelium of the skin, but not in internal organs except liver showing weak TTX-positive reaction. In two specimens collected in Guyana, none of the toxins were detected.",
keywords = "Atelopus hoogmoedi, Guiana Shield, Monoclonal antibody, Tetrodotoxin, Tissue distribution",
author = "Dietrich Mebs and Max Lorentz and Mari Yotsu-Yamashita and R{\"o}{\ss}ler, {Daniela C.} and Raffael Ernst and Stefan L{\"o}tters",
note = "Funding Information: We would like to thank Kentaro Kawatsu, Osaka Prefectural Institute of Public Health, for providing the TTX-antibodies. Christine Elbert has performed excellent immunohistochemical work. This work was funded by KAKENHI Grant-in-Aid for Scientific Research (B) (no. 17H03809 ) and Innovative Area, Frontier Research on Chemical Communications (no. 17H06406 ) from the Japan Society for the Promotion of Science to M.Y.Y. R.E. was supported by a research grant from the German Research Foundation ( DFG ER 589/2–1 ). Permission to conduct research in Guyana was provided by the EPA Guyana under research permit number 180609 BR 112, and fieldwork was made possible through the Iwokrama International Centre and the Guyana Forestry Commission, particularly by R. Thomas. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = aug,
doi = "10.1016/j.toxicon.2018.05.011",
language = "English",
volume = "150",
pages = "175--179",
journal = "Toxicon",
issn = "0041-0101",
publisher = "Elsevier Ltd.",
}