Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus

Yusuke Gokon; Fumiyoshi Fujishima; Yusuke Taniyama; Hirotaka Ishida; Taku Yamagata; Takashi Sawai; Miwa Uzuki; Hirofumi Ichikawa; Yuko Itakura; Kazutomi Takahashi; Nobuhisa Yajima; Motohisa Hagiwara; Akiko Nishida; Yohei Ozawa; Tsutomu Sakuma; Kazuhiro Sakamoto; Masashi Zuguchi; Masahiro Saito; Takashi Kamei; Hironobu Sasano

doi:10.1111/pin.12922

Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus

Yusuke Gokon, Fumiyoshi Fujishima, Yusuke Taniyama, Hirotaka Ishida, Taku Yamagata, Takashi Sawai, Miwa Uzuki, Hirofumi Ichikawa, Yuko Itakura, Kazutomi Takahashi, Nobuhisa Yajima, Motohisa Hagiwara, Akiko Nishida, Yohei Ozawa, Tsutomu Sakuma, Kazuhiro Sakamoto, Masashi Zuguchi, Masahiro Saito, Takashi Kamei, Hironobu Sasano

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5 Citations (Scopus)

Abstract

Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and is predisposed to esophageal adenocarcinoma (EAC). EAC is an exemplar model of inflammation-associated cancer. Glucocorticoids suppress inflammation through glucocorticoid receptor (GR) and serum- and glucocorticoid-induced kinase-1 (Sgk1) expressions. Therefore, we immunolocalized GR and Sgk1 in EAC and the adjacent BE tissues and studied their association with clinical disease course in 87 patients with EAC who underwent surgical resection (N = 58) or endoscopic submucosal dissection (N = 29). Low GR and Sgk1 expressions in adjacent BE tissues were associated with adverse clinical outcomes (P = 0.0008 and 0.034, respectively). Patients with low Sgk1 expression in EAC cells exhibited worse overall survival (P = 0.0018). In multivariate Cox regression analysis, low GR expression in the adjacent nonmalignant BE tissues was significantly associated with worse overall survival (P = 0.023). The present study indicated that evaluation of GR and Sgk1 expressions in both the EAC cells and adjacent nonmalignant BE tissues could help to predict clinical outcomes following endoscopic and surgical treatments. In particular, the GR status in BE tissues adjacent to EAC was an independent prognostic factor.

Original language	English
Pages (from-to)	355-363
Number of pages	9
Journal	Pathology International
Volume	70
Issue number	6
DOIs	https://doi.org/10.1111/pin.12922
Publication status	Published - 2020 Jun 1

Keywords

Barrett's esophagus
clinical outcome
esophageal adenocarcinoma
glucocorticoid receptor
serum- and glucocorticoid-induced kinase-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/pin.12922

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Gokon, Y., Fujishima, F., Taniyama, Y., Ishida, H., Yamagata, T., Sawai, T., Uzuki, M., Ichikawa, H., Itakura, Y., Takahashi, K., Yajima, N., Hagiwara, M., Nishida, A., Ozawa, Y., Sakuma, T., Sakamoto, K., Zuguchi, M., Saito, M., Kamei, T., & Sasano, H. (2020). Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus. Pathology International, 70(6), 355-363. https://doi.org/10.1111/pin.12922

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title = "Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus",

abstract = "Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and is predisposed to esophageal adenocarcinoma (EAC). EAC is an exemplar model of inflammation-associated cancer. Glucocorticoids suppress inflammation through glucocorticoid receptor (GR) and serum- and glucocorticoid-induced kinase-1 (Sgk1) expressions. Therefore, we immunolocalized GR and Sgk1 in EAC and the adjacent BE tissues and studied their association with clinical disease course in 87 patients with EAC who underwent surgical resection (N = 58) or endoscopic submucosal dissection (N = 29). Low GR and Sgk1 expressions in adjacent BE tissues were associated with adverse clinical outcomes (P = 0.0008 and 0.034, respectively). Patients with low Sgk1 expression in EAC cells exhibited worse overall survival (P = 0.0018). In multivariate Cox regression analysis, low GR expression in the adjacent nonmalignant BE tissues was significantly associated with worse overall survival (P = 0.023). The present study indicated that evaluation of GR and Sgk1 expressions in both the EAC cells and adjacent nonmalignant BE tissues could help to predict clinical outcomes following endoscopic and surgical treatments. In particular, the GR status in BE tissues adjacent to EAC was an independent prognostic factor.",

keywords = "Barrett's esophagus, clinical outcome, esophageal adenocarcinoma, glucocorticoid receptor, serum- and glucocorticoid-induced kinase-1",

author = "Yusuke Gokon and Fumiyoshi Fujishima and Yusuke Taniyama and Hirotaka Ishida and Taku Yamagata and Takashi Sawai and Miwa Uzuki and Hirofumi Ichikawa and Yuko Itakura and Kazutomi Takahashi and Nobuhisa Yajima and Motohisa Hagiwara and Akiko Nishida and Yohei Ozawa and Tsutomu Sakuma and Kazuhiro Sakamoto and Masashi Zuguchi and Masahiro Saito and Takashi Kamei and Hironobu Sasano",

note = "Publisher Copyright: {\textcopyright} 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd",

year = "2020",

month = jun,

day = "1",

doi = "10.1111/pin.12922",

language = "English",

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Gokon, Y, Fujishima, F , Taniyama, Y , Ishida, H, Yamagata, T, Sawai, T, Uzuki, M, Ichikawa, H, Itakura, Y, Takahashi, K, Yajima, N, Hagiwara, M, Nishida, A, Ozawa, Y, Sakuma, T, Sakamoto, K, Zuguchi, M, Saito, M, Kamei, T & Sasano, H 2020, 'Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus', Pathology International, vol. 70, no. 6, pp. 355-363. https://doi.org/10.1111/pin.12922

TY - JOUR

T1 - Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus

AU - Gokon, Yusuke

AU - Fujishima, Fumiyoshi

AU - Taniyama, Yusuke

AU - Ishida, Hirotaka

AU - Yamagata, Taku

AU - Sawai, Takashi

AU - Uzuki, Miwa

AU - Ichikawa, Hirofumi

AU - Itakura, Yuko

AU - Takahashi, Kazutomi

AU - Yajima, Nobuhisa

AU - Hagiwara, Motohisa

AU - Nishida, Akiko

AU - Ozawa, Yohei

AU - Sakuma, Tsutomu

AU - Sakamoto, Kazuhiro

AU - Zuguchi, Masashi

AU - Saito, Masahiro

AU - Kamei, Takashi

AU - Sasano, Hironobu

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and is predisposed to esophageal adenocarcinoma (EAC). EAC is an exemplar model of inflammation-associated cancer. Glucocorticoids suppress inflammation through glucocorticoid receptor (GR) and serum- and glucocorticoid-induced kinase-1 (Sgk1) expressions. Therefore, we immunolocalized GR and Sgk1 in EAC and the adjacent BE tissues and studied their association with clinical disease course in 87 patients with EAC who underwent surgical resection (N = 58) or endoscopic submucosal dissection (N = 29). Low GR and Sgk1 expressions in adjacent BE tissues were associated with adverse clinical outcomes (P = 0.0008 and 0.034, respectively). Patients with low Sgk1 expression in EAC cells exhibited worse overall survival (P = 0.0018). In multivariate Cox regression analysis, low GR expression in the adjacent nonmalignant BE tissues was significantly associated with worse overall survival (P = 0.023). The present study indicated that evaluation of GR and Sgk1 expressions in both the EAC cells and adjacent nonmalignant BE tissues could help to predict clinical outcomes following endoscopic and surgical treatments. In particular, the GR status in BE tissues adjacent to EAC was an independent prognostic factor.

AB - Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and is predisposed to esophageal adenocarcinoma (EAC). EAC is an exemplar model of inflammation-associated cancer. Glucocorticoids suppress inflammation through glucocorticoid receptor (GR) and serum- and glucocorticoid-induced kinase-1 (Sgk1) expressions. Therefore, we immunolocalized GR and Sgk1 in EAC and the adjacent BE tissues and studied their association with clinical disease course in 87 patients with EAC who underwent surgical resection (N = 58) or endoscopic submucosal dissection (N = 29). Low GR and Sgk1 expressions in adjacent BE tissues were associated with adverse clinical outcomes (P = 0.0008 and 0.034, respectively). Patients with low Sgk1 expression in EAC cells exhibited worse overall survival (P = 0.0018). In multivariate Cox regression analysis, low GR expression in the adjacent nonmalignant BE tissues was significantly associated with worse overall survival (P = 0.023). The present study indicated that evaluation of GR and Sgk1 expressions in both the EAC cells and adjacent nonmalignant BE tissues could help to predict clinical outcomes following endoscopic and surgical treatments. In particular, the GR status in BE tissues adjacent to EAC was an independent prognostic factor.

KW - Barrett's esophagus

KW - clinical outcome

KW - esophageal adenocarcinoma

KW - glucocorticoid receptor

KW - serum- and glucocorticoid-induced kinase-1

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U2 - 10.1111/pin.12922

DO - 10.1111/pin.12922

M3 - Article

C2 - 32173971

AN - SCOPUS:85081715424

SN - 1320-5463

VL - 70

SP - 355

EP - 363

JO - Pathology International

JF - Pathology International

IS - 6

ER -

Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus

Abstract

Keywords

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