Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers

Masato Noguchi; Atsushi Kobayashi; Shin Ichiro Shoda; Toru Nakayama

Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers

Masato Noguchi, Atsushi Kobayashi, Shin Ichiro Shoda, Toru Nakayama

ENG - Biomolecular Engineering

Tohoku University

Research output: Contribution to conference › Paper › peer-review

Abstract

It is well known that protected acyclic sugar carbonates are useful glycosyl donors for chemical glycosylation reaction. Cyclic sugar derivatives, 1,2-(9-carbonylglycopyranoses(glucose carbonate 1), are potential glycosyl donors for glycosidase-catalyzed glycosylation reaction. Here we report the synthesis of glucose carbonate and the screening of hydrolases that recognize this compound. We synthesized the glucose carbonate from D-glucose via three steps. The enzymatic activity was found in some enzyme preparations, such as Sumizyme MC, from Rhizopus sp. in basic media, and in some α-glucosidase preparations from Rhizopus sp. and Bacillus sp. in acidic media.

Original language	English
Pages	4978
Number of pages	1
Publication status	Published - 2005
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sept 20 → 2005 Sept 22

Conference

Conference	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	05/9/20 → 05/9/22

Keywords

Glycosyl donor substrate
Glycosyl hydrolase
Glycosylation reaction

Cite this

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title = "Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers",

abstract = "It is well known that protected acyclic sugar carbonates are useful glycosyl donors for chemical glycosylation reaction. Cyclic sugar derivatives, 1,2-(9-carbonylglycopyranoses(glucose carbonate 1), are potential glycosyl donors for glycosidase-catalyzed glycosylation reaction. Here we report the synthesis of glucose carbonate and the screening of hydrolases that recognize this compound. We synthesized the glucose carbonate from D-glucose via three steps. The enzymatic activity was found in some enzyme preparations, such as Sumizyme MC, from Rhizopus sp. in basic media, and in some α-glucosidase preparations from Rhizopus sp. and Bacillus sp. in acidic media.",

keywords = "Glycosyl donor substrate, Glycosyl hydrolase, Glycosylation reaction",

author = "Masato Noguchi and Atsushi Kobayashi and Shoda, {Shin Ichiro} and Toru Nakayama",

year = "2005",

language = "English",

pages = "4978",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

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TY - CONF

T1 - Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers

AU - Noguchi, Masato

AU - Kobayashi, Atsushi

AU - Shoda, Shin Ichiro

AU - Nakayama, Toru

PY - 2005

Y1 - 2005

N2 - It is well known that protected acyclic sugar carbonates are useful glycosyl donors for chemical glycosylation reaction. Cyclic sugar derivatives, 1,2-(9-carbonylglycopyranoses(glucose carbonate 1), are potential glycosyl donors for glycosidase-catalyzed glycosylation reaction. Here we report the synthesis of glucose carbonate and the screening of hydrolases that recognize this compound. We synthesized the glucose carbonate from D-glucose via three steps. The enzymatic activity was found in some enzyme preparations, such as Sumizyme MC, from Rhizopus sp. in basic media, and in some α-glucosidase preparations from Rhizopus sp. and Bacillus sp. in acidic media.

AB - It is well known that protected acyclic sugar carbonates are useful glycosyl donors for chemical glycosylation reaction. Cyclic sugar derivatives, 1,2-(9-carbonylglycopyranoses(glucose carbonate 1), are potential glycosyl donors for glycosidase-catalyzed glycosylation reaction. Here we report the synthesis of glucose carbonate and the screening of hydrolases that recognize this compound. We synthesized the glucose carbonate from D-glucose via three steps. The enzymatic activity was found in some enzyme preparations, such as Sumizyme MC, from Rhizopus sp. in basic media, and in some α-glucosidase preparations from Rhizopus sp. and Bacillus sp. in acidic media.

KW - Glycosyl donor substrate

KW - Glycosyl hydrolase

KW - Glycosylation reaction

UR - http://www.scopus.com/inward/record.url?scp=33645634239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645634239&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645634239

SP - 4978

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers

Abstract

Conference

Keywords

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