TY - JOUR
T1 - Glucose uptake by individual skeletal muscles during running using whole-body positron emission tomography
AU - Fujimoto, Toshihiko
AU - Itoh, Masatoshi
AU - Tashiro, Manabu
AU - Yamaguchi, Keiichiro
AU - Kubota, Kazuo
AU - Ohmori, Hiroaki
N1 - Funding Information:
Acknowledgements This work was supported by the 13th Research Aid for Medical Health Science by the Meiji Life Foundation for Health and Welfare. The authors thank Dr. Nuutila and Dr. Knuuti of the Turku PET Center, Finland, the entire staff at the Cyclotron and Radioisotope Center and Department of Medicine and Science in Sports and Exercise, Tohoku University.
PY - 2000
Y1 - 2000
N2 - The purpose of this study was to examine, by positron emission tomography (PET), the distribution of [18F]fluoro-deoxy-glucose ([18F]FDG) uptake by human muscles during 35 min of running. Thirteen healthy male subjects were studied, seven of whom participated in the exercise study. Running intensity was kept constant such that the subjects' heart rates were maintained at between 140 and 150 beats per minute. [18F]FDG [62.9 (14.8) MBq, mean (SD)] was injected after 15 min of running. PET imaging was started immediately after the running ended. The ratio of [18F]FDG uptake by muscles in runners to that in control subjects (r-c ratio) varied from three to six for the muscles of the foot and leg below the knee joint. The r-c ratio of the medial head of the gastrocnemius (MG) was higher than that of its lateral head (LG). The r-c ratio of the rectus femoris (RF) was lower than that of the other three muscles of the quadriceps femoris (QF). The r-c ratio of inactive muscles located above the waist was approximately 0.7. These results suggest that, during the moderate running of this study: (1) glucose uptake by muscles of the foot and leg below the knee joint clearly increases, (2) the r-c ratio differs significantly among the skeletal muscles, which act synergistically, and (3) glucose uptake by inactive skeletal muscles decreases.
AB - The purpose of this study was to examine, by positron emission tomography (PET), the distribution of [18F]fluoro-deoxy-glucose ([18F]FDG) uptake by human muscles during 35 min of running. Thirteen healthy male subjects were studied, seven of whom participated in the exercise study. Running intensity was kept constant such that the subjects' heart rates were maintained at between 140 and 150 beats per minute. [18F]FDG [62.9 (14.8) MBq, mean (SD)] was injected after 15 min of running. PET imaging was started immediately after the running ended. The ratio of [18F]FDG uptake by muscles in runners to that in control subjects (r-c ratio) varied from three to six for the muscles of the foot and leg below the knee joint. The r-c ratio of the medial head of the gastrocnemius (MG) was higher than that of its lateral head (LG). The r-c ratio of the rectus femoris (RF) was lower than that of the other three muscles of the quadriceps femoris (QF). The r-c ratio of inactive muscles located above the waist was approximately 0.7. These results suggest that, during the moderate running of this study: (1) glucose uptake by muscles of the foot and leg below the knee joint clearly increases, (2) the r-c ratio differs significantly among the skeletal muscles, which act synergistically, and (3) glucose uptake by inactive skeletal muscles decreases.
KW - PET
KW - Running
KW - Skeletal muscle
KW - [F]FDG
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U2 - 10.1007/s004210000254
DO - 10.1007/s004210000254
M3 - Article
C2 - 11138567
AN - SCOPUS:0034530651
SN - 1439-6319
VL - 83
SP - 297
EP - 302
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 4-5
ER -
