Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

Tienan Jin, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)

Abstract

(Chemical Equation Presented) The reaction of the internal alkynyl ketones 1 (n = 1) under the combined catalyst, AuCl3 and AgSbF6, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n = 0) under the combined catalyst, AuCl3 and AgOTf, afforded the cyclic enones 3.

Original languageEnglish
Pages (from-to)5259-5262
Number of pages4
JournalOrganic Letters
Volume9
Issue number25
DOIs
Publication statusPublished - 2007 Dec 6

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