Gold nanoparticle-induced formation of artificial protein capsids

Ali D. Malay; Jonathan G. Heddle; Satoshi Tomita; Kenji Iwasaki; Naoyuki Miyazaki; Koji Sumitomo; Hisao Yanagi; Ichiro Yamashita; Yukiharu Uraoka

doi:10.1021/nl3002155

Gold nanoparticle-induced formation of artificial protein capsids

Ali D. Malay, Jonathan G. Heddle, Satoshi Tomita, Kenji Iwasaki, Naoyuki Miyazaki, Koji Sumitomo, Hisao Yanagi, Ichiro Yamashita, Yukiharu Uraoka

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.

Original language	English
Pages (from-to)	2056-2059
Number of pages	4
Journal	Nano Letters
Volume	12
Issue number	4
DOIs	https://doi.org/10.1021/nl3002155
Publication status	Published - 2012 Apr 11
Externally published	Yes

Keywords

Gold nanoparticles
artificial capsid
nanospheres
protein remodeling

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl3002155

Cite this

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AU - Malay, Ali D.

AU - Heddle, Jonathan G.

AU - Tomita, Satoshi

AU - Iwasaki, Kenji

AU - Miyazaki, Naoyuki

AU - Sumitomo, Koji

AU - Yanagi, Hisao

AU - Yamashita, Ichiro

AU - Uraoka, Yukiharu

PY - 2012/4/11

Y1 - 2012/4/11

N2 - Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.

AB - Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.

KW - Gold nanoparticles

KW - artificial capsid

KW - nanospheres

KW - protein remodeling

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JF - Nano Letters

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Gold nanoparticle-induced formation of artificial protein capsids

Abstract

Keywords

ASJC Scopus subject areas

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