TY - JOUR
T1 - Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications
AU - Wagner, Torsten
AU - Molina, Roberto
AU - Yoshinobu, Tatsuo
AU - Kloock, Joachim P.
AU - Biselli, Manfred
AU - Canzoneri, Michelangelo
AU - Schnitzler, Thomas
AU - Schöning, Michael J.
N1 - Funding Information:
The authors gratefully thank the Federal Ministry for Education and Research (BMBF) and the “Ministerium für Wissenschaft, Forschung und Technologie des Landes Nordrhein-Westfalen” for partial financial support.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - The light-addressable potentiometric sensor is a promising technology platform for multi-sensor applications and lab-on-chip devices. However, many prior LAPS developments suffer from their lack in terms of non-portability, insufficient robustness, complicate handling, etc. Hence, portable and robust LAPS-based measurement devices have been investigated by the authors recently. In this work, a "chip card"-based light-addressable potentiometric sensor system is presented. The utilisation of ordinary "chip cards" allows an easy handling of different sensor chips for a wide range of possible applications. The integration of the electronic and the mechanical set-up into a single reader unit results in a compact design with the benefits of portability and low required space. In addition, the presented work includes a new multi-frequency measurement procedure, based on an FFT algorithm, which enables the simultaneous real-time measurement of up to 16 sensor spots. The comparison between the former batch-LAPS and the new FFT-based LAPS set-up will be presented. The immobilisation of biological cells (CHO: Chinese hamster ovary) demonstrates the possibility to record their metabolic activity with 16 measurement spots on the same chip. Furthermore, a Cd2+-selective chalcogenide-glass layer together with a pH-sensitive Ta2O5 layer validates the use of the LAPS for chemical multi-sensor applications.
AB - The light-addressable potentiometric sensor is a promising technology platform for multi-sensor applications and lab-on-chip devices. However, many prior LAPS developments suffer from their lack in terms of non-portability, insufficient robustness, complicate handling, etc. Hence, portable and robust LAPS-based measurement devices have been investigated by the authors recently. In this work, a "chip card"-based light-addressable potentiometric sensor system is presented. The utilisation of ordinary "chip cards" allows an easy handling of different sensor chips for a wide range of possible applications. The integration of the electronic and the mechanical set-up into a single reader unit results in a compact design with the benefits of portability and low required space. In addition, the presented work includes a new multi-frequency measurement procedure, based on an FFT algorithm, which enables the simultaneous real-time measurement of up to 16 sensor spots. The comparison between the former batch-LAPS and the new FFT-based LAPS set-up will be presented. The immobilisation of biological cells (CHO: Chinese hamster ovary) demonstrates the possibility to record their metabolic activity with 16 measurement spots on the same chip. Furthermore, a Cd2+-selective chalcogenide-glass layer together with a pH-sensitive Ta2O5 layer validates the use of the LAPS for chemical multi-sensor applications.
KW - FFT
KW - LAPS
KW - Light-addressable potentiometric sensor
KW - Metabolic activity
KW - Multi-sensor
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U2 - 10.1016/j.electacta.2007.04.006
DO - 10.1016/j.electacta.2007.04.006
M3 - Article
AN - SCOPUS:35148891262
SN - 0013-4686
VL - 53
SP - 305
EP - 311
JO - Electrochimica Acta
JF - Electrochimica Acta
IS - 2
ER -