Heart rate variability and ambulatory blood pressure monitoring in young patients with hypertrophic cardiomyopathy

Sadamitsu Yanagi, Masao Yoshinaga, Hitoshi Horigome, Yuji Tanaka, Naoki Fusazaki, Yuji Matsuoka, Atsushi Shimago, Toshiro Fukushige, Taisuke Eguchi, Koichi Tokuda, Junichiro Nishi, Yukiharu Kono, Yuichi Nomura, Koichiro Miyata, Yoshifumi Kawano

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Sudden cardiac death commonly occurs in young patients with hypertrophic cardiomyopathy (HCM); however, their heart rate variability (HRV) and blood pressure (BP) response to daily life activities is not well known. Methods and Results: HRV and ambulatory BP monitoring were performed in 20 patients (age range: 7-21 years) and 57 age-matched healthy volunteers (age range: 10-22 years). Time domain variables and spectral data were obtained at hourly intervals throughout the day. To determine the BP response to daily life activities, the ratios of the mean BP and pulse pressure in the morning, afternoon, and night to those during sleeping were calculated. The association between the BP level and HRV was also evaluated. The HCM patients showed significantly increased sympathovagal imbalance and decreased parasympathetic activity in the early morning, around noon, and in the early evening. This abnormality was independent of cardiac symptoms. Symptomatic patients showed a significantly lower systolic BP response in the morning, and a higher incidence of dissociation between sympathetic activity and BP response than asymptomatic patients. Conclusion: An abnormal BP response in the presence of impaired HRV appears to be predictive for cardiac events in young patients with HCM.

Original languageEnglish
Pages (from-to)757-762
Number of pages6
JournalCirculation Journal
Issue number8
Publication statusPublished - 2004 Aug
Externally publishedYes


  • Ambulatory blood pressure monitoring
  • Autonomic activity
  • Children
  • Heart rate variability
  • Hypertrophic cardiomyopathy
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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