TY - JOUR
T1 - Heat diffusion characteristics of magnetite nanoparticles dispersed hydro-gel in alternating magnetic field
AU - Suto, Makoto
AU - Kosukegawa, Hiroyuki
AU - Maruta, Kaoru
AU - Ohta, Makoto
AU - Tohji, Kazuyuki
AU - Jeyadevan, Balachandran
N1 - Funding Information:
This work was supported by Grant-in-Aid for Basic Research #(A) 17201021 from the Ministry of Education, Science, Culture and Sport of Japan. We thank Dr. Fujita from Graduate School of Engineering Department of Materials Science for his kind assistance in helping with alternative susceptibility measurement.
PY - 2009/10
Y1 - 2009/10
N2 - Heat diffusion characteristics of a spherical heat source dispersing magnetite nanoparticles (MNPs) in hydro-gel were investigated numerically and experimentally to evaluate the conditions required for magnetic fluid hyperthermia (MFH). Numerical estimation assumed one-dimensional spherical model and constant heat evolution. Experimental observation was carried out by exposing the magnetite-dispersed hydro-gel in an AC magnetic field with strength and frequency of 3.2 kA/m and 600 kHz, respectively. The temperature distribution observed along the radial axis of the spherical heat source agreed well with the theoretical estimation quantitatively and qualitatively. However, the minor difference existed between the theory and experiment was due to the variation in experimentally determined and actual particle size distributions. Thus, we could conclude that the proposed algorithm could be extended to be used in the estimation of the temperature distribution in intravital conditions with blood flow, metabolism etc., to arrive at biologically significant conclusions helpful for MFH cancer treatment.
AB - Heat diffusion characteristics of a spherical heat source dispersing magnetite nanoparticles (MNPs) in hydro-gel were investigated numerically and experimentally to evaluate the conditions required for magnetic fluid hyperthermia (MFH). Numerical estimation assumed one-dimensional spherical model and constant heat evolution. Experimental observation was carried out by exposing the magnetite-dispersed hydro-gel in an AC magnetic field with strength and frequency of 3.2 kA/m and 600 kHz, respectively. The temperature distribution observed along the radial axis of the spherical heat source agreed well with the theoretical estimation quantitatively and qualitatively. However, the minor difference existed between the theory and experiment was due to the variation in experimentally determined and actual particle size distributions. Thus, we could conclude that the proposed algorithm could be extended to be used in the estimation of the temperature distribution in intravital conditions with blood flow, metabolism etc., to arrive at biologically significant conclusions helpful for MFH cancer treatment.
KW - AC magnetic field
KW - Heat diffusion
KW - Hyperthermia
KW - Magnetic fluid
KW - Magnetite
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U2 - 10.1016/j.jmmm.2009.06.067
DO - 10.1016/j.jmmm.2009.06.067
M3 - Article
AN - SCOPUS:67651244873
SN - 0304-8853
VL - 321
SP - 3483
EP - 3487
JO - Journal of Magnetism and Magnetic Materials
JF - Journal of Magnetism and Magnetic Materials
IS - 20
ER -
