TY - GEN
T1 - Hemodynamic analysis of intracranial aneurysms with atherosclerosis
AU - Sugiyama, Shinichiro
AU - Funamoto, K.
AU - Nakayama, T.
AU - Niizuma, K.
AU - Tominaga, T.
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2014.
PY - 2014
Y1 - 2014
N2 - Intracranial aneurysms can have atherosclerotic wall properties that may be important in predicting aneurysm history. This study aimed to investigate hemodynamic characteristics of atherosclerotic legions in intracranial aneurysms. We conducted computational fluid dynamic analyses of 30 aneurysms using patient-derived geometries and inlet flow rates. Among 30 aneurysms, seven atherosclerotic lesions with remarkable yellow lipid deposition were identified in five aneurysms. All seven atherosclerotic lesions were spatially agreed with the area exposed to stagnant blood flow. Univariate analysis revealed that male (P = 0.031), cigarette smoking (P = 0.047) and the exposure to stagnant blood flow (P = 0.024) are significantly related to atherosclerotic lesion formation on the aneurysmal wall. Of those variables that influenced atherogenesis, the variable male (P = 0.0046) and the exposure to stagnant flow (P = 0.0037) remained significant in the multivariate regression model. In conclusion, male sex and stagnant blood flow inside aneurysms were independent risk factors for atherosclerosis in intracranial aneurysms.
AB - Intracranial aneurysms can have atherosclerotic wall properties that may be important in predicting aneurysm history. This study aimed to investigate hemodynamic characteristics of atherosclerotic legions in intracranial aneurysms. We conducted computational fluid dynamic analyses of 30 aneurysms using patient-derived geometries and inlet flow rates. Among 30 aneurysms, seven atherosclerotic lesions with remarkable yellow lipid deposition were identified in five aneurysms. All seven atherosclerotic lesions were spatially agreed with the area exposed to stagnant blood flow. Univariate analysis revealed that male (P = 0.031), cigarette smoking (P = 0.047) and the exposure to stagnant blood flow (P = 0.024) are significantly related to atherosclerotic lesion formation on the aneurysmal wall. Of those variables that influenced atherogenesis, the variable male (P = 0.0046) and the exposure to stagnant flow (P = 0.0037) remained significant in the multivariate regression model. In conclusion, male sex and stagnant blood flow inside aneurysms were independent risk factors for atherosclerosis in intracranial aneurysms.
KW - Cerebral aneurysm
KW - Hemodynamics
KW - Stagnation
KW - Wall shear stress
UR - http://www.scopus.com/inward/record.url?scp=84928264122&partnerID=8YFLogxK
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U2 - 10.1007/978-3-319-02913-9_188
DO - 10.1007/978-3-319-02913-9_188
M3 - Conference contribution
AN - SCOPUS:84928264122
T3 - IFMBE Proceedings
SP - 738
EP - 740
BT - The 15th International Conference on Biomedical Engineering, ICBME 2013
A2 - Goh, James
PB - Springer Verlag
T2 - 15th International Conference on Biomedical Engineering, ICBME 2013
Y2 - 4 December 2013 through 7 December 2013
ER -