Hemodynamic analysis of microcirculation in malaria infection

Hitoshi Kondo; Yohsuke Imai; Takuji Ishikawa; Ken Ichi Tsubota; Takami Yamaguchi

doi:10.1007/s10439-009-9641-1

Hemodynamic analysis of microcirculation in malaria infection

Hitoshi Kondo, Yohsuke Imai, Takuji Ishikawa, Ken Ichi Tsubota, Takami Yamaguchi

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook's law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.

Original language	English
Pages (from-to)	702-709
Number of pages	8
Journal	Annals of Biomedical Engineering
Volume	37
Issue number	4
DOIs	https://doi.org/10.1007/s10439-009-9641-1
Publication status	Published - 2009 Apr

Keywords

Blood flow
Computational fluid dynamics
Infectious disease
Malaria
Red blood cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10439-009-9641-1

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title = "Hemodynamic analysis of microcirculation in malaria infection",

abstract = "Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook's law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.",

keywords = "Blood flow, Computational fluid dynamics, Infectious disease, Malaria, Red blood cell",

author = "Hitoshi Kondo and Yohsuke Imai and Takuji Ishikawa and Tsubota, {Ken Ichi} and Takami Yamaguchi",

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doi = "10.1007/s10439-009-9641-1",

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AU - Kondo, Hitoshi

AU - Imai, Yohsuke

AU - Ishikawa, Takuji

AU - Tsubota, Ken Ichi

AU - Yamaguchi, Takami

N1 - Funding Information: This study was made possible by the following grants: the ‘‘Revolutionary Simulation Software (RSS21)’’ project, supported by the next-generation IT program of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Grants-in-Aid for Scientific Research from MEXT, and JSPS Scientific Research in Priority Areas (768) ‘‘Biomechanics at Micro-and Nano-scale Levels’’ and Scientific Research(A) No.16200031 ‘‘Mechanism of the Formation, Destruction, and Movement of Thrombi Responsible for Ischemia of Vital Organs’’.

PY - 2009/4

Y1 - 2009/4

N2 - Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook's law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.

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Hemodynamic analysis of microcirculation in malaria infection

Abstract

Keywords

UN SDGs

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