Hereditary sensory and autonomic neuropathy types 4 and 5: Review and proposal of a new rehabilitation method

Arito Yozu, Nobuhiko Haga, Tetsuro Funato, Dai Owaki, Ryosuke Chiba, Jun Ota

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


Although pain is unpleasant, it should serve as a reminder for individuals to avoid similar damaging incidents in the future. Hereditary sensory and autonomic neuropathy (HSAN) includes genetic disorders involving various sensory and autonomic dysfunctions. They are classified by the mode of inheritance, clinical features, and related genes. HSAN type 4 (HSAN-4) and type 5 (HSAN-5) are characterized by insensitivity to pain and thermal sensation. Further, HSAN-4 is accompanied by decreased sweating and intellectual disabilities. These characteristics of HSAN-4 and -5 result in many clinical features, such as pediatric, psychiatric, orthopedic, oral, dermatological, and ophthalmological problems. Orthopedic problems include destructive injuries such as multiple fractures and joint dislocation. Studies on gait have shown greater speed and higher heel contact angular velocity in HSAN-4 and -5 patients compared with controls. Studies on grasp-lift-holding tasks have shown higher grasp force and fluctuations in acceleration of the object. We believe that these findings represent outcomes of deficient motor learning. We propose a new rehabilitation method for patients with HSAN-4 and -5, with the aim of decreasing their destructive injuries.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalNeuroscience Research
Publication statusPublished - 2016 Mar 1


  • Congenital insensitivity to pain
  • Hereditary sensory and autonomic neuropathy (HSAN)
  • Motor learning
  • Multiple fractures
  • Nerve growth factor (NGF)
  • Rehabilitation

ASJC Scopus subject areas

  • Neuroscience(all)


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