Heterocycles Synthesis via Co-Catalyzed C-H Bond Functionalization

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2 Citations (Scopus)


This chapter provides an overview of synthetic methods for heterocyclic compounds that capitalize on cobalt-catalyzed C-H functionalization, with a particular focus on the progress in the last several years (till the early 2015). Various heterocycle-forming reactions are classified and discussed according to the type and the nature of the cobalt catalysts involved. The cobalt catalysts include (i) low-valent (Co0 or CoI) catalysts that undergo inner-sphere activation of C(sp2)-H bonds through oxidative addition, (ii) high-valent (CoIII) catalysts that undergo inner-sphere activation of C(sp2)-H bonds through deprotonative metalation, and (iii) CoII-porphyrin catalysts that decompose azide and diazo compounds to form CoIII nitrene and carbene radical species, respectively, which then undergo intramolecular hydrogen-atom abstraction from C(sp3)-H bonds.

Original languageEnglish
Title of host publicationTransition Metal-Catalyzed Heterocycle Synthesis via C-H Activation
Number of pages22
ISBN (Electronic)9783527691920
ISBN (Print)9783527338887
Publication statusPublished - 2016 Jan 12


  • C-C bond formation
  • C-H activation
  • C-N bond formation
  • Cobalt
  • Heterocycles


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