Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Takahiro Ugai; Atsushi Minami; Ryuya Fujii; Mizuki Tanaka; Hiroki Oguri; Katsuya Gomi; Hideaki Oikawa

doi:10.1039/c4cc09512j

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Takahiro Ugai, Atsushi Minami, Ryuya Fujii, Mizuki Tanaka, Hiroki Oguri, Katsuya Gomi, Hideaki Oikawa

AGR - Agricultural Chemistry

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

Original language	English
Pages (from-to)	1878-1881
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	10
DOIs	https://doi.org/10.1039/c4cc09512j
Publication status	Published - 2015 Feb 4

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author = "Takahiro Ugai and Atsushi Minami and Ryuya Fujii and Mizuki Tanaka and Hiroki Oguri and Katsuya Gomi and Hideaki Oikawa",

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AU - Ugai, Takahiro

AU - Minami, Atsushi

AU - Fujii, Ryuya

AU - Tanaka, Mizuki

AU - Oguri, Hiroki

AU - Gomi, Katsuya

AU - Oikawa, Hideaki

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PY - 2015/2/4

Y1 - 2015/2/4

N2 - A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

AB - A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

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Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Abstract

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