Heterologous production of asperipin-2a: Proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

Ying Ye, Taro Ozaki, Myco Umemura, Chengwei Liu, Atsushi Minami, Hideaki Oikawa

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and determination of its absolute structure. Notably, the characteristic bicyclic structure was likely constructed by a single oxidase containing the DUF3328 domain.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number1
DOIs
Publication statusPublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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