TY - JOUR
T1 - High β-hydroxybutyrate concentration in liver and skeletal muscle of newly hatched chicks
AU - Ohtsu, Haruhiko
AU - Sato, Kan
AU - Nishida, Hiroshi
AU - Akiba, Yukio
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Characteristic changes in ketone body concentrations in blood, liver, and skeletal muscle were investigated in detail in newly hatched chicks. The concentration of β-hydroxybutyrate in the blood was maximal at hatch (0 day), markedly decreased to 3 days, then maintained at low levels, up to 14 days of age. The concentration of acetoacetate in blood, on the other hand, did not change after hatching but remained lower than that of β-hydroxybutyrate at all ages. In liver and muscles, the concentration of β-hydroxybutyrate changed in a manner similar to that in the blood. The muscle to blood ratio of the β-hydroxybutyrate concentration on days -1 and 0 was significantly higher than those at 1 through 14 days post-hatch. These results show that newly hatched chicks have the same high ketone body concentrations in the skeletal muscle, blood and liver. It is, hence, suggested that uptake of β-hydroxybutyrate by muscles is substantial or that ketogenesis, if any, occurs in muscles immediately before and after hatching of chicks.
AB - Characteristic changes in ketone body concentrations in blood, liver, and skeletal muscle were investigated in detail in newly hatched chicks. The concentration of β-hydroxybutyrate in the blood was maximal at hatch (0 day), markedly decreased to 3 days, then maintained at low levels, up to 14 days of age. The concentration of acetoacetate in blood, on the other hand, did not change after hatching but remained lower than that of β-hydroxybutyrate at all ages. In liver and muscles, the concentration of β-hydroxybutyrate changed in a manner similar to that in the blood. The muscle to blood ratio of the β-hydroxybutyrate concentration on days -1 and 0 was significantly higher than those at 1 through 14 days post-hatch. These results show that newly hatched chicks have the same high ketone body concentrations in the skeletal muscle, blood and liver. It is, hence, suggested that uptake of β-hydroxybutyrate by muscles is substantial or that ketogenesis, if any, occurs in muscles immediately before and after hatching of chicks.
KW - Acetoacetate
KW - Ketone bodies
KW - Liver
KW - Newly hatched chick
KW - Skeletal muscle
KW - β-Hydroxybutyrate
UR - http://www.scopus.com/inward/record.url?scp=0037365953&partnerID=8YFLogxK
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U2 - 10.1016/S1095-6433(02)00353-7
DO - 10.1016/S1095-6433(02)00353-7
M3 - Article
C2 - 12600671
AN - SCOPUS:0037365953
SN - 1095-6433
VL - 134
SP - 625
EP - 629
JO - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
IS - 3
ER -